Hormonal Modulation of the Proinflammatory Cytokines, Leptin and Plasminogen Activator Inhibitor-1 in Healthy Postmenopausal Women
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Yayincilik
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study we aimed to determine the levels of TNF-alpha, IL-6, IL-1 beta, PAI-1, leptin in healthy premenopausal and postmenopausal subjects who were evaluated before and after hormone replacement therapy (HRT). Twenty premenoposal woman with regular cycles and 45 postmenopausal women were included in the study. Twenty-five of the postmenopausal women received conjugated estrogen (CCE) + medroxyprogesterone acetate (MPA) and the other 20 received 17-beta estradiol + norethisterone acetate (NETA). The levels of the above identified cytokines in these two treatment groups were compared with that of the healthy pemenopausal group as well as with each other before and after 6 months of HRT. IL-1 levels were significantly higher in the postmenopausal group before HRT when compared to the premenopausal group. Levels of IL-1 were elevated even more after 6 months of HRT. IL-6 was significantly higher in postmenopausal group before HRT compared to the premenopausal group. After 6 months of HRT there was no significant decrease in levels of IL-6. TNF-alpha was significantly higher in postmenopausal group before HRT compared to the premenopausal group. No significant decrease was seen after HRT. PAI-1 was significantly higher in the postmenaposal group before HRT compared to the premenopausal group. After 6 months of HRT, there was a significant decrease in levels of PAI-1. Leptin levels were not different between the premenopausal and the postmenopausal groups (p=0.97). But leptin levels were higher in the postmenopausal group after receiving HRT for 6 months. Menopausal status and HRT may be the causative factor of biochemical proinflammatory response, lepitn. fibrinolytic process and coagulation in healthy postmenopausal women.
Açıklama
Anahtar Kelimeler
Menopause, proinflammatory cytokines, leptin, plasminojen activator inhibitor-1
Kaynak
Haseki Tip Bulteni-Medical Bulletin of Haseki
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
46
Sayı
3
