Intestinal blood flow alterations in postoperative intraabdominal adhesion formation and the role of endothelin-1 blockade

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dc.authorscopusid6603565782
dc.authorscopusid6603321936
dc.authorscopusid6602177993
dc.authorscopusid9280121300
dc.contributor.authorGünal, Ömer
dc.contributor.authorGhandour, Salah
dc.contributor.authorDeniz, Mustafa
dc.contributor.authorAslaner, Arif
dc.date.accessioned2024-09-25T19:43:59Z
dc.date.available2024-09-25T19:43:59Z
dc.date.issued2006
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBACKGROUND: The current study was planned to investigate intestinal blood flow alterations and the role of ET-1 receptor blockade in the formation of postoperative intraperitoneal adhesion formation. METHODS: Twenty-eight adult Wistar Albino rats weighing between 250 g and 300 g were divided into four groups. Control group (group 1; n=7) did not undergo any operation. Sham group (group 2; n=7) had only laparotomy. In the adhesion group (group 3; n=7), peritoneal patch (1x1 cm) excision from the right abdominal wall and cecal abrasion were done as "adhesion model operation". One week following this, treatment group (group 4; n=7) received a non-selective ET-1 receptor blocking agent bosentan (30 mg/kg, IP) intra-abdominally, once a day for four days. Intestinal blood flow through the superior mesenteric artery was measured, on postoperative seventh day. Adhesion severity and extension as well as myeloperoxidase activity in the adhesion were calculated. RESULTS: Mean intestinal blood flow significantly increased in adhesion group (81.9±5.6 ml/100 g) when compared to group 1 (65.5±1.2 ml/100 g). Bosentan caused a significant decrease (44.3±6.9 ml/100 g) in intestinal blood flow when compared to group 1 and group 2. Sham group (62.2±1 ml/100 g) had similar blood flow level with the control group (65.5±1.2 ml/100g). Adhesion scores were similar in adhesion and Bosentan groups. Sham group had almost no adhesions. Myeloperoxidase activity in adhesion tissue was significantly higher in bosentan group. CONCLUSION: Non-selective ET-1 receptor blockade has no effect on prevention of the formation of intra-abdominal adhesion, but causes a decrease in intestinal blood flow. Adhesion formation increases intestinal blood flow. Adhesion formation is accompanied by increased polymorphonuclear infiltration despite bosentan treatment.en_US
dc.identifier.endpage106en_US
dc.identifier.issn1300-6738
dc.identifier.issue2en_US
dc.identifier.pmid16676248en_US
dc.identifier.scopus2-s2.0-33645673906en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage101en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12589
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.relation.ispartofUlusal Travma ve Acil Cerrahi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAdhesionsen_US
dc.subjectBosentanen_US
dc.subjectEndothelinsen_US
dc.subjectRats, Wistaren_US
dc.subjectReceptors, Endothelin/ antagonists & inhibitorsen_US
dc.titleIntestinal blood flow alterations in postoperative intraabdominal adhesion formation and the role of endothelin-1 blockadeen_US
dc.title.alternativeAmeliyat sonrasi karin içi yapişiklik oluşumunda ba?irsak kan akimindaki de?işiklikler ve endotelin-1 blo?unun rolü]en_US
dc.typeArticleen_US

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