Radiation-induced oxidative injury of the ileum and colon is alleviated by glucagon-like peptide-1 and -2

Basit Öğe Kaydı
dc.authorid0000-0001-6584-902Xen_US
dc.authorid0000-0002-6054-9244en_US
dc.authorid0000-0003-1320-9105en_US
dc.authorid0000-0002-7914-1169
dc.authorid0000-0003-1320-9105
dc.contributor.authorDeniz, Mustafa
dc.contributor.authorAtasoy, Beste M.
dc.contributor.authorDane, Faysal
dc.contributor.authorCan, Güray
dc.contributor.authorErzik, Can
dc.date.accessioned2021-06-23T19:42:12Z
dc.date.available2021-06-23T19:42:12Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: The present study was conducted to characterize the possible therapeutic effects of glucagon-like peptide (GLP)-1 and GLP-2 against oxidative damage in the ileum and colon of irradiated rats. Methods and materials: Sprague-Dawley rats of both sexes received either a single dose of GLP-1 (0.1 nmol/kg, intraperitoneally, ip; n = 6) 10 min before abdominal irradiation (IR) or two consecutive doses of GLP-2 (7 nmol/kg, ip; n = 6) at 30 and 10 min before IR, while another group was administered vehicle (n = 6) 10 min before IR. Control rats (n = 6) received vehicle treatment without IR. On the fourth day of IR, samples from ileum and colon were removed for histological analysis, for the determination of myeloperoxidase (MPO) activity, malondialdehyde (MDA) and glutathione (GSH) levels, as well as DNA fragmentation ratio, an index of apoptosis. Results: IR-induced oxidative injury in the colonic tissue of vehicle-treated rats, evidenced by elevated MDA levels and MPO activity, as well as depleted colonic GSH levels, was reversed by GLP-2, while GLP-1 reduced IR-induced elevations in colonic MDA levels. IR-induced injury with elevated ileal MDA levels was reduced by GLP-1, while replenishment in GSH was observed in GLP-2-treated rats. Conclusion: Current findings suggest that GLP-1 and GLP-2 appear to have protective roles in the irradiation-induced oxidative damage of the gut by inhibiting neutrophil infiltration and subsequent activation of inflammatory mediators that induce lipid peroxidation. Copyright (C) 2015, The Egyptian Society of Radiation Sciences and Applications. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.en_US
dc.identifier.doi10.1016/j.jrras.2015.01.010
dc.identifier.endpage242en_US
dc.identifier.issn1687-8507
dc.identifier.issue2en_US
dc.identifier.startpage234en_US
dc.identifier.urihttps://doi.org/10.1016/j.jrras.2015.01.010
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8388
dc.identifier.volume8en_US
dc.identifier.wosWOS:000215712700012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorCan, Güray
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal Of Radiation Research And Applied Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGLP-1en_US
dc.subjectGLP-2en_US
dc.subjectRadiation-enteritisen_US
dc.subjectMyeloperoxidaseen_US
dc.subjectGlutathioneen_US
dc.titleRadiation-induced oxidative injury of the ileum and colon is alleviated by glucagon-like peptide-1 and -2en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
mustafa-deniz.pdf
Boyut:
2.38 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu