Sağlıklı kan donörlerinde Hepatit B virus, Hepatit C virus ve Hepatit D virus seroprevalansı
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Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: İki farklı yörede bulunan Araştırma ve Uygulama Hastanesi Kan bankasına başvuran sağlıklı kan donörlerinde kronik viral hepatit etkenleri olan HBV, HCV ve HDV seroprevalansı EIA yöntemi ile araştırıldı. Bu çalışmanın amacı, batı ve güneydoğu Anadolu bölgelerinin kronik viral hepatit seroprevalansını sağlıklı kan donörlerinde saptamak ve yöresel farklılığı literatür eşliğinde irdelemektir. Gereç ve Yöntemler: Bu çalışma iki gruptan oluşmaktadır. Birinci grup 2004-2006 yılları arasında Şanlıurfa, ikinci grup 2007-2009 yılları arasında Bolu’da Üniversite Hastanesi Kan Bankasında yapılmıştır. Çalışma olguları sağlıklı kan donörlerinden, gönüllülük ilkesine göre seçilmiştir. Donörlerin kronik viral hepatit göstergelerinden HBsAg / anti-HCV makro EIA (Abbott, Axyms, UK), anti-HDV testleri mikro EIA (Abbot, UK) yöntemi ile çalışıldı. Tüm olguların yaşları, meslekleri, bulaş olabilecek özgeçmişleri ve doğum yerleri ayrıntılı olarak sorgulanmıştır. Bul gu lar: Birinci grupta: toplam 19.250 gönüllü sağlıklı kan dönoründe 565 olguda HBsAg (%2,9) ve 104 olguda anti-HCV (%0,5) pozitif olarak bulundu. HBsAg pozitif olan toplam 194 olgunun beşinde anti-HDV (%2,5) olumlu bulundu. İkinci grupta ise toplam 2012 kan dönoründe sırası ile HBsAg 24 (%1,19), anti-HCV 5 (%0,24) olguda pozitif bulunurken, anti-HDV olumluluğuna rastlanılmamıştır. So nuç: Güneydoğu ve batı bölgesinde iki farklı şehir populasyonları karşılaştırıldığı zaman kronik viral hepatit etkenlerinin batı bölgesinde anlamlı olarak daha az olduğu görülmüştür. Daha önceleri güneydoğuda bölgesinde kronik viral hepatit seroprevalansı daha yüksek iken son yıllarda düşüş göstermesi ve özellikle batı bölgesinde anti-HDV pozitifliğinin olmaması dikkat çekici bulunmuştur. Kronik viral hepatitlerin seropozitifliğinin azalmasında rutin aşılama, eğitim ve bilgilendirim programları ile gerçekleştiği katına varılmıştır.
ABS TRACT Objective: Training and research Hospital in the two different region, healthy volunteer blood donors were admitted to Blood Bank which serological markers to chronic viral hepatitis HBV, HCV and HDV seroprevalance was investigated by EIA. The aim of this study is to determine seropositivity indicating chronic hepatitis through west and southeast regions and to debate the difference between two regions according to literature.Materials and Methods: This study was performed in two groups. First group was enrolled in Sanliurfa between 2004-2006 years, whereas second group was programmed in Bolu between 2007-2009 years. Both of them were taken University Hospital Blood Bank. Healthy blood donors were chosen on a voluntary basis. The serological markers of donors HBV and HCV were studied by macro EIA (Abbott Axsym UK), whereas HDV markers in the sera of patients with HBsAg positive by micro EIA (Abbott UK). All the patients’ ages, professions, birth places and history of transmission were questioned in detail. Results: In the first group; 565 (2.9%) HBsAg and 104 (0.5%) anti-HCV positive cases were found in a total of 19.250 healthy blood donors. Only 194 HBsAg positive cases were followed and monitories in which 5 (2.5%) ones of all were found to be anti-HDV positive. In the second group including 2012 blood donors, HBsAg and anti-HCV positivity were found respectively 24 (1.19%) and 5 (0.24%) besides no anti-HDV positivity. All subjects’ mean age was 33.9(between 18-71 years). Conclusion: When comparing population of both Southeast and West cities in aspect of chronic viral hepatitis markers, it is found to be significantly less in West. Previously chronic viral hepatitis seroprevalance is higher in the Southeast region to show decline in recent years and especially in the western region has a remarkable absence of and anti-HDV positivity. We assume that the decrease in the rate seropositivity of chronic viral hepatitis is due to routine immunization and education programs.
ABS TRACT Objective: Training and research Hospital in the two different region, healthy volunteer blood donors were admitted to Blood Bank which serological markers to chronic viral hepatitis HBV, HCV and HDV seroprevalance was investigated by EIA. The aim of this study is to determine seropositivity indicating chronic hepatitis through west and southeast regions and to debate the difference between two regions according to literature.Materials and Methods: This study was performed in two groups. First group was enrolled in Sanliurfa between 2004-2006 years, whereas second group was programmed in Bolu between 2007-2009 years. Both of them were taken University Hospital Blood Bank. Healthy blood donors were chosen on a voluntary basis. The serological markers of donors HBV and HCV were studied by macro EIA (Abbott Axsym UK), whereas HDV markers in the sera of patients with HBsAg positive by micro EIA (Abbott UK). All the patients’ ages, professions, birth places and history of transmission were questioned in detail. Results: In the first group; 565 (2.9%) HBsAg and 104 (0.5%) anti-HCV positive cases were found in a total of 19.250 healthy blood donors. Only 194 HBsAg positive cases were followed and monitories in which 5 (2.5%) ones of all were found to be anti-HDV positive. In the second group including 2012 blood donors, HBsAg and anti-HCV positivity were found respectively 24 (1.19%) and 5 (0.24%) besides no anti-HDV positivity. All subjects’ mean age was 33.9(between 18-71 years). Conclusion: When comparing population of both Southeast and West cities in aspect of chronic viral hepatitis markers, it is found to be significantly less in West. Previously chronic viral hepatitis seroprevalance is higher in the Southeast region to show decline in recent years and especially in the western region has a remarkable absence of and anti-HDV positivity. We assume that the decrease in the rate seropositivity of chronic viral hepatitis is due to routine immunization and education programs.
Açıklama
Anahtar Kelimeler
Blood donors, Chronic Viral Hepatitis, HBsAg, Anti-HCV, Anti-HDV, Kan Donörleri, Kronik Viral Hepatit, HBsAg, Anti-HCV, Anti-HDV
Kaynak
Viral Hepatitis Journal
WoS Q Değeri
Scopus Q Değeri
Cilt
18
Sayı
1
