Carbohydrate antigen-125 and N-terminal pro-brain natriuretic peptide levels: Compared in heart-failure prognostication

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dc.authorscopusid25121970100
dc.authorscopusid8615642100
dc.authorscopusid35274318900
dc.authorscopusid35274448800
dc.authorscopusid36105714600
dc.authorscopusid14030823200
dc.authorscopusid8587924200
dc.contributor.authorOrdu, Serkan
dc.contributor.authorOzhan, Hakan
dc.contributor.authorAlemdar, Recai
dc.contributor.authorAydin, Mesut
dc.contributor.authorCaglar, Onur
dc.contributor.authorYuksel, Hatice
dc.contributor.authorKandis, Hayati
dc.date.accessioned2024-09-25T19:44:19Z
dc.date.available2024-09-25T19:44:19Z
dc.date.issued2012
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractCarbohydrate antigen-125 (CA-125) is emerging as a prognostic biomarker of risk in heart failure. In a prospective study, we compared the prognostic values of CA-125 and aminoterminal pro-brain natriuretic peptide (NT-proBNP) in patients with stable heart failure. We enrolled 102 consecutive chronic, stable, systolic-heart-failure patients (68 men and 34 women; median age, 71 yr) from November 2008 through February 2010. We measured baseline NT-proBNP and CA-125 levels and compared their prognostic values. The primary endpoint was all-cause death and other major adverse events, defined as hospitalization for decompensated heart failure or acute coronary syndrome. During a mean follow-up period of 14 ± 2 months, 12 patients died and 35 others sustained major adverse events. We found that CA-125 level significantly correlated with New York Heart Association functional class, pulmonary artery pressure, microalbuminuria, creatine kinase-MB fraction, and hemoglobin, albumin, and NT-proBNP levels. Upon receiver operating characteristic curve analysis, CA-125 and NT-proBNP had similar accuracy in predicting major adverse events and death: for major adverse events, area under the curve (AUC) was 0.699 for CA-125 (P=0.002) and 0.696 for NT-proBNP (P=0.002); for death, AUC was 0.784 for CA-125 (P=0.003) and 0.824 for NT-proBNP (P=0.001). Multivariate Cox regression analysis showed that CA-125 levels greater than 32 U/mL and NT-proBNP levels greater than 5,300 pg/mL had independent prognostic value for major adverse events and death. We conclude that baseline CA-125 and NT-proBNP levels are comparably reliable as heart-failure markers, and that CA-125 can be used for prognosis prediction in heart failure. © 2012 by the Texas Heart® Institute, Houston.en_US
dc.identifier.endpage35en_US
dc.identifier.issn1526-6702
dc.identifier.issue1en_US
dc.identifier.pmid22412224en_US
dc.identifier.scopus2-s2.0-84865836027en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage30en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12749
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTexas Heart Institute Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectBiological markers/blooden_US
dc.subjectBrain/blooden_US
dc.subjectCA-125 antigen/blooden_US
dc.subjectDiagnostic testsen_US
dc.subjectHealth status indicatorsen_US
dc.subjectHeart failure/physiopathologyen_US
dc.subjectNatriuretic peptideen_US
dc.subjectPredictive value of testsen_US
dc.subjectRoutine/utilizationen_US
dc.subjectSensitivity and specificityen_US
dc.titleCarbohydrate antigen-125 and N-terminal pro-brain natriuretic peptide levels: Compared in heart-failure prognosticationen_US
dc.typeArticleen_US

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