The frequency of plasminogen activator inhibitor (pai) polymorphism and its effects on recurrent ivf failure.

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dc.contributor.authorErsoy, Ebru
dc.contributor.authorYılmaz, Nafiye
dc.contributor.authorErsoy, Ali
dc.contributor.authorKarataş, Ahmet
dc.contributor.authorEngin Üstün, Yaprak
dc.date.accessioned2021-06-23T19:43:10Z
dc.date.available2021-06-23T19:43:10Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: Recurrent IVF failure is still a challenging clinical situation. Plasminogen Activator Inhibitor (PAI) enzyme polymorphisms have been recently cited to be associated with endometrial receptivity which is about the differential effect of PAI-1 enzyme activity on extracellular matrix degradation (1). Here we aimed to investigate the frequency of different PAI polymorphism groups and their effects on IVF outcomes. DESIGN: Retrospective cross-sectional study. MATERIALS AND METHODS: One hundred seventy-nine nulliparous patients who had a history of two IVF failure at least and attended to the Assisted Reproduction Clinics of our tertiary care institution between January 2013 and January 2015 were included in this study. PAI-1 gene polymorphisms were detected using PCR prior to any controlled ovarian hyperstimulation protocols. The patients were merged into three groups as followings: 5G/5G (Normal), 4G/5G (Heterozygote), 4G/4G (Homozygote). Individual characteristics and IVF outcomes were compared among groups. RESULTS: The ages, FSH levels (Day 3), mean number of oocytes retrieved, fertilisation rate and the number of transferred good quality embryos were comparable among groups. Clinical pregnancy rates were 25%, 34.1%, 34.9%, respectively, and there was no significant difference among them. Also, live birth rates were comparable among groups. CONCLUSIONS: The present study indicated that different PAI polymorphism states had no effect on IVF outcomes of patients who had recurrent VF failure.Footnote of the table: CI: Confidence interval, PAI: Plasminogen Activator Inhibitor. Values were given as meanstandard deviation, median (range), or number (percentage).en_US
dc.identifier.doi10.1016/j.fertnstert.2016.07.527
dc.identifier.endpageE180en_US
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue3en_US
dc.identifier.startpageE180en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2016.07.527
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8710
dc.identifier.volume106en_US
dc.identifier.wosWOS:000449962500459en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorKarataş, Ahmet
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility And Sterilityen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPlasminogen Activator Inhibitor (PAI)en_US
dc.subjectEnzyme
dc.subjectAssisted Reproduction Clinics
dc.subjectPAI-1
dc.titleThe frequency of plasminogen activator inhibitor (pai) polymorphism and its effects on recurrent ivf failure.en_US
dc.typeConference Objecten_US

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