Depression in pregnancy is associated with decreased glutathione peroxidase activity in fetal cord blood

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dc.contributor.authorCamkurt, Mehmet Akif
dc.contributor.authorFindikli, Ebru
dc.contributor.authorBakacak, Murat
dc.contributor.authorKaraaslan, Mehmet Fatih
dc.contributor.authorTolun, Fatma Inanc
dc.contributor.authorTuman, Taha Can
dc.date.accessioned2024-09-25T19:57:37Z
dc.date.available2024-09-25T19:57:37Z
dc.date.issued2016
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractThe investigation of fetal cord blood (FCB) during child delivery has created a novel topic in the field of psychiatric research. The umbilical vein receives nutrients and oxygen from the mother's circulation and transports them to the fetal circulation. Investigating fetal cord blood during delivery is beneficial for understanding the fetal environment. Depression in pregnancy is associated with medical and emotional burdens. In this study, we aimed to investigate glutathione peroxidase (Gpx) and myeloperoxidase (MPO) activity in the FCB of depressed mothers and healthy controls. Our study included 45 depressed mothers and 59 healthy controls. The FCB samples were collected from the umbilical vein during delivery. We found that Gpx levels were significantly decreased in the FCB of depressed mothers than healthy controls, medians were 0.14 U/ml and 0.16 respectively, Z: -3.567 and p < 0.001. MPO levels were similar in both groups, medians were 1.0 U/L and 1.2 U/L respectively, Z: -1.837 and p:0.066. Depression in pregnancy may be associated with decreased antioxidant levels, and this condition may cause an oxidative load, which may lead to improper brain development. Future studies should be performed in larger samples to clarify our preliminary results. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpsychires.2016.04.008
dc.identifier.endpage60en_US
dc.identifier.issn0022-3956
dc.identifier.issn1879-1379
dc.identifier.pmid27174401en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpsychires.2016.04.008
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13501
dc.identifier.volume79en_US
dc.identifier.wosWOS:000378179000009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofJournal of Psychiatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectDepressionen_US
dc.subjectPragnancyen_US
dc.subjectAntioxidanten_US
dc.subjectFetal corden_US
dc.subjectUmbilical corden_US
dc.subjectGlutathione peroxidaseen_US
dc.subjectMyeloperoxidaseen_US
dc.titleDepression in pregnancy is associated with decreased glutathione peroxidase activity in fetal cord blooden_US
dc.typeArticleen_US

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