Development of molecularly imprinted polymer-based optical sensor for the sensitive penicillin g detection in milk

dc.authorid0000-0003-3260-1639en_US
dc.authorid0000-0001-7292-7241en_US
dc.authorid0000-0001-7548-5741en_US
dc.contributor.authorSafran, Volkan
dc.contributor.authorGöktürk, Ilgım
dc.contributor.authorBakhshpour, Monireh
dc.contributor.authorYılmaz, Fatma
dc.contributor.authorDenizli, Adil
dc.date.accessioned2023-07-05T06:09:52Z
dc.date.available2023-07-05T06:09:52Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Gerede Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.description.abstractIn this study, selective and sensitive Penicillin G (PEN-G) antibiotic detection from both aqueous solution and milk samples using molecular imprinting technique was performed by surface plasmon resonance sensor. For this purpose, PEN-G imprinted poly(2-Hydroxyethyl methacrylate-N-methacroyl-(L)-cysteine methyl ester-gold nanoparticles-N-methacryloyl-L-phenylalanine methyl ester (MIP-AuNPs) nanosensor was prepared. Control experiments were carried out via the nanosensor without the addition of AuNPs (MIP) to examine the effect of gold nanoparticles (AuNPs) incorporated to increase the surface plasmon resonance signal response. Moreover, to evaluate the imprinting efficiency, non-imprinted (NIP-AuNPs) nanosensor was designed using the same polymerization recipe except the addition of the PEN-G molecule. Characterization studies of MIP, MIP-AuNPs and NIP-AuNPs nanosensors were performed with FTIR-ATR spectrophotometer. Also, MIP-AuNPs and NIP-AuNPs nanosensors were characterized by atomic force microscopy, ellipsometer and contact angle measurements. Imprinting efficiency (I.F: 7.83) for the MIP-AuNPs nanosensor was determined by comparing it with the NIP-AuNPs nanosensor. The MIP-AuNPs nanosensor was 9.87 times more selective for the target PEN-G molecule than amoxicillin, and 16.78-times than ampicillin. In addition, the amount of PEN-G in milk selected as a real sample was measured by spiking 5 ppb PEN-G into the milk.en_US
dc.identifier.citationSafran, V., Göktürk, I., Bakhshpour, M., Yılmaz, F., & Denizli, A. (2021). Development of Molecularly Imprinted Polymer‐Based Optical Sensor for the Sensitive Penicillin G Detection in Milk. ChemistrySelect, 6(43), 11865-11875.en_US
dc.identifier.doi10.1002/slct.202103058
dc.identifier.endpage11875en_US
dc.identifier.issn2365-6549
dc.identifier.issue43en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage11865en_US
dc.identifier.urihttp://dx.doi.org/10.1002/slct.202103058
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11237
dc.identifier.volume6en_US
dc.identifier.wosWOS:000720942400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYılmaz, Fatma
dc.language.isoenen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.relation.ispartofChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGold Nanoparticlesen_US
dc.subjectMolecularly Imprinted Polymeren_US
dc.subjectNanosensoren_US
dc.subjectPenicillin Gen_US
dc.subjectSurface Plasmon Resonanceen_US
dc.subjectBeta-Lactam Antibioticsen_US
dc.titleDevelopment of molecularly imprinted polymer-based optical sensor for the sensitive penicillin g detection in milken_US
dc.typeArticleen_US

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