Combination hyperbaric oxygen and temozolomide therapy in c6 rat glioma model

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dc.authoridYAGMURLU, KAAN/0000-0002-7635-2809
dc.authoridToklu, Akin Savas/0000-0003-4900-8559
dc.authoridBilir, Ayhan/0009-0009-9399-5927
dc.contributor.authorDagistan, Yasar
dc.contributor.authorKaraca, Ismail
dc.contributor.authorBozkurt, Erol Rustu
dc.contributor.authorOzar, Engin
dc.contributor.authorYagmurlu, Kaan
dc.contributor.authorToklu, Akin
dc.contributor.authorBilir, Ayhan
dc.date.accessioned2024-09-25T19:58:36Z
dc.date.available2024-09-25T19:58:36Z
dc.date.issued2012
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractPURPOSE: Temozolomide (TMZ) has anti-tumor activity in patients with malignant glioma. Hyperbaric oxygen (HBO) may enhance the efficacy of certain therapies that are limited because of the hypoxic tumor microenvironment. We examined the combined effects of TMZ-HBO in a rat glioma model. METHODS: After stereotactic injection of C6/LacZ rat glioma cells into the Wistar rats brain, the rats were randomly assigned to three treatment groups [group 1, control treatment; group 2, TMZ alone; group 3, a combination of TMZ and HBO]. Rats were sacrificed 18 days after treatment, and number of intra-/peri-tumoral vessels, microendothelial proliferations, immunohistochemistry and necrotic area were evaluated. RESULTS: Tumoral tissue was stained only sparsely with GFAP. Temozolomide treatment was significantly decreased in tumor tissue intratumoral vessel number / total tumor area level. The level of Ki67 was significantly decreased in the tumor tissue of the group 3. Additionally, the total necrotic area / total tumor volume (%) was decreased significantly in tumor tissue of the group 3 rats compared to group1 and 2. CONLUSION: The combination of hyperbaric oxygen with temozolomide produced an important reduction in glioma growth and effective approach to the treatment of glioblastoma.en_US
dc.identifier.endpage387en_US
dc.identifier.issn0102-8650
dc.identifier.issue6en_US
dc.identifier.pmid22666755en_US
dc.identifier.startpage383en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13648
dc.identifier.volume27en_US
dc.identifier.wosWOS:000304830100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectGliomaen_US
dc.subjectGlioblastomaen_US
dc.subjectTemozolomideen_US
dc.subjectHyperbaric Oxygenationen_US
dc.subjectRatsen_US
dc.titleCombination hyperbaric oxygen and temozolomide therapy in c6 rat glioma modelen_US
dc.typeArticleen_US

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