Spectral analysis and biological activity assessment of silver doped hydroxyapatite

Yükleniyor...
Küçük Resim

Tarih

2021

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

TAYLOR & FRANCIS LTD

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

In this study, the hydroxyapatite biomaterials are produced by the precipitation method and the role of silver doping within the different molar ratios of 2.0, 5.0, and 10.0% are investigated with some fundamental analysis, including powder XRD, SEM, EDS, FTIR, Raman, and material densities. In vitro biocompatibility assessment is conducted with cytotoxicity and agar diffusion tests. Moreover, genotoxicity tests determine whether the biomaterials produced cause the mutations or not. In addition, a hemolytic effect test examines the variation of hemolytic behavior of compounds. Also, the cell migration experiments inspect the influence of silver ion levels in biomaterials on many biological processes. The experimental results reveal that the honeycomb-patterned morphological structures are obtained for all the products. FTIR and Raman analyses reveal that the dramatic changes in the characteristic functional group peaks are obtained with the increment in the amount of silver ions. The experimental parts related to the biocompatibility assessment of the study show that there seems to be deterioration in biocompatibility as the silver ion-doping level increases in the system. To sum up, the ideal doping value for bone tissue engineering applications is found to be 2%.

Açıklama

Anahtar Kelimeler

Hydroxyapatite, Silver Doping, Biocompability, Cell Migration, Thin-Films, Antibacterial

Kaynak

Journal of Asian Ceramic Societies

WoS Q Değeri

Q2

Scopus Q Değeri

Q2

Cilt

9

Sayı

4

Künye

Erdem, U., Bozer, B. M., Turkoz, M. B., Metin, A. U., Yıldırım, G., Turk, M., & Nezir, S. (2021). Spectral analysis and biological activity assessment of silver doped hydroxyapatite. Journal of Asian Ceramic Societies, 9(4), 1524-1545.