Evaluation of Total Oxidative Level and Total Antioxidant Capacity in Cases with Chronic Viral Hepatitis

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dc.authoridSELEK, Sahabettin/0000-0003-1235-3957
dc.contributor.authorSirmatel, Fatma
dc.contributor.authorDuygu, Fazilet
dc.contributor.authorCelik, Hakim
dc.contributor.authorSelek, Sahabettin
dc.contributor.authorSirmatel, Ocal
dc.contributor.authorGursoy, Bensu
dc.contributor.authorEris, Fatma Nur
dc.date.accessioned2024-09-25T20:00:08Z
dc.date.available2024-09-25T20:00:08Z
dc.date.issued2009
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: Oxidative stress is described as an instability between production of free radicals from cells and antioxidant defence of the body. The aim of the study was to investigate the correlation of total antioxidant capacity (TAC) and total oxidative level (TOL) with the severity of the disease and reliability of these parameters in the follow up of response to treatment in cases with chronic viral hepatitis (CVH). Methods: Between January 2004-March 2006, 73 cases with CVH were included in the study. The ages of the patients ranged from 15 to 70 years. Diagnosis of CVH was confirmed by clinical serological, and biochemical markers. The cases were divided into two groups: Group 1 as HBsAg-positive or anti-HCV-positive but HBV DNA or HCV RNA-negative and Group 2 as proven CVH. TAC, lipid hydroperoxide (LOOH), and TOL of the sera were studied according to Erel method, and statistically evaluated by 2 test in all the cases. Results: TAC, LOOH and TOL were found statistically significantly different between two groups. Average values of TAC were 1.8 +/- 0.5 mmol Trolox-Eqv./L and 1.0 +/- 0.15 mmol Trolox-Eqv./L in Group 1 and Group 2 (p=0.0001) respectively. Average values of LOOH were 5.3 +/- 2.8 mu mol H2O2 in Group 1 and 10.6 +/- 10.1 mu mol H2O2 in Group 2 (p=0.002). Average values of TOL were 10.2 +/- 5.9 mu mol H2O2 Eqv./L in Group 1 and 18.5 +/- 16.6 mu mol H2O2 Eqv./L in Group 2 (p=0.004). Conclusions: TAC was found higher, and TOL and LOOH were found lower in Group 1 than Group 2. The evaluation of plasma TAC, TOS ve LOOH levels may be important activation markers for the follow up of CVH.en_US
dc.identifier.endpage96en_US
dc.identifier.issn1301-143X
dc.identifier.issn1309-1484
dc.identifier.issue3en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/14082
dc.identifier.volume22en_US
dc.identifier.wosWOS:000420870800006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAvesen_US
dc.relation.ispartofKlimik Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectTotal antioxidant capacityen_US
dc.subjecttotal oxidative levelen_US
dc.subjectchronic viral hepatitisen_US
dc.titleEvaluation of Total Oxidative Level and Total Antioxidant Capacity in Cases with Chronic Viral Hepatitisen_US
dc.typeArticleen_US

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