Evaluation of the effect of galanin and exercise on anxiety in rats by open field and elevated plus maze tests

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dc.authorid0000-0001-6458-5296
dc.authorid0000-0002-0000-3768
dc.authorid0000-0002-6817-4512
dc.authorid0000-0001-5380-0819
dc.contributor.authorMermerci , Asuman
dc.contributor.authorÖzmerdivenli, Recep
dc.contributor.authorOrallar, Hayriye
dc.contributor.authorBeyazçiçek, Ersin
dc.contributor.authorSungur, Mehmet Ali
dc.date.accessioned2021-06-23T18:51:35Z
dc.date.available2021-06-23T18:51:35Z
dc.date.issued2018
dc.departmentBAİBÜ, Ziraat Fakültesi, Kanatlı Hayvan Yetiştiriciliği Bölümüen_US
dc.description.abstractAim: Anxiety, known as worry, considered normal in everyday life, and also it is a type of behavior developed to protect the organism. The aim of this study is to investigate the effects of exogenous galanin given with exercise on anxiety. Material and Methods: In this study 96 adult male Wistar Albino rats were used. Rats were divided into 8 groups with twelve animals, and 4 of the groups were given regular exercise for 6 weeks. Galanin was administered intraperitoneally (IP) and intracerebroventricular (ICV) in half of the groups and saline was injected into the control group of each group with the same methods. At the end of the sixth week, open field and elevated plus maze tests were applied to the rats, and these tests recorded with the camera. The recordings of the both tests were analyzed, and total distance and speed values, the time spent in the open field test and the time spent in the closed arm of elevated plus maze were compared. Results: In the open field test were determined that in general, the total distance (p<0.001) and the speed increased (p<0.001) in rats injected with ICV compared to the rats injected with IP. There is no significant difference was detected in terms of exercise and galanin interaction. Also the total distance (p=0,032) and the speed increased (p=0,010) in rats injected with ICV compared to the rats injected with IP. In elevated plus maze test, exercise and galanin interaction were not found to be statistically significant, however the interaction between the injection pattern and the given substance was found to be significant in terms of time spent in the closed arm (p=0.020) and speed (p=0.032). Conclusion: Although it has been shown that central administration of galanin may have anxiolytic activity, this effect has not changed with exercise, and also it has been determined that exercise with galanin has no effect on this activity. © 2018, Duzce University Medical School. All rights reserved.en_US
dc.identifier.doi10.18678/dtfd.490123
dc.identifier.endpage68en_US
dc.identifier.issn1307-671X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85059017462en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage63en_US
dc.identifier.trdizinid386124en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.490123
dc.identifier.urihttps://hdl.handle.net/20.500.12491/3883
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorOrallar, Hayriye
dc.language.isotren_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDuzce Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnxietyen_US
dc.subjectElevated plus maze testen_US
dc.subjectExerciseen_US
dc.subjectGalaninen_US
dc.subjectOpen field testen_US
dc.subjectRaten_US
dc.titleEvaluation of the effect of galanin and exercise on anxiety in rats by open field and elevated plus maze testsen_US
dc.title.alternativeGalanin ve egzersizin ratlarda anksiyete üzerine etkisinin açık alan ve yükseltilmiş artı labirent testleri ile değerlendirilmesien_US
dc.typeArticleen_US

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