Dantrolene: In doxorubicin toxicity

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dc.authorid0000-0002-1452-3879
dc.authorid0000-0003-1251-3148
dc.authorid0000-0002-9054-3134
dc.contributor.authorBüyükokuroğlu, Mehmet Emin
dc.contributor.authorTaysi, Seyithan
dc.contributor.authorBüyükavcı, Mustafa
dc.contributor.authorMemişoğulları, Ramazan
dc.date.accessioned2021-06-23T18:54:08Z
dc.date.available2021-06-23T18:54:08Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractDoxorubicin (DOX) is a widely used anthracycline in the treatment of hematological and solid tumors. However, there are serious toxic effects on cardiovascular and hematopoietic system, which limits the use of the drug. This study examines the effect of dantrolene (5 and 10 mg kg-1) on DOX (20 mg kg-1, i.p.)-induced cardiotoxicity and hematotoxicity in normal rats. Change in nitric oxide (NO.) levels in cardiac tissue were measured and hemoglobin (Hb), white blood cells (WBC), red blood cells (RBC) and platelets were counted with an automatic counter. Pretreatment of rats with 5 and 10 mg kg-1 doses of dantrolene, markedly reduced the NO . levels in the cardiac tissue. The hematotoxicity was characterized by leukopenia and thrombocytopenia that appeared after 48 h of single dose DOX (20 mg kg-1) administration. Dantrolene (5 and 10 mg kg-1) 0.5 h before doxorubicin injection ameliorated the hematotoxicity induced by doxorubicin. These results showed that dantrolene has provided a protective effect against DOX-induced nitrosative stress in the heart and hematotoxicity.en_US
dc.identifier.endpage4042en_US
dc.identifier.issn0970-7077
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-34347258491en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage4035en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4257
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34347258491&partnerID=40&md5=a097223be9898d48863c31c6c5e3f6c2
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorMemişoğulları, Ramazan
dc.language.isoenen_US
dc.relation.ispartofAsian Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiotoxicityen_US
dc.subjectDantroleneen_US
dc.subjectDoxorubicinen_US
dc.subjectHematotoxicityen_US
dc.titleDantrolene: In doxorubicin toxicityen_US
dc.typeArticleen_US

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