Mean platelet volume in patients with non-alcoholic fatty liver disease

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dc.authorscopusid8615642100
dc.authorscopusid35274448800
dc.authorscopusid7007162316
dc.authorscopusid19337952100
dc.authorscopusid35338946100
dc.authorscopusid25621439500
dc.authorscopusid15838098900
dc.contributor.authorOzhan, Hakan
dc.contributor.authorAydin, Mesut
dc.contributor.authorYazici, Mehmet
dc.contributor.authorYazgan, Omer
dc.contributor.authorBasar, Cengiz
dc.contributor.authorGungor, Adem
dc.contributor.authorOnder, Elif
dc.date.accessioned2024-09-25T19:44:14Z
dc.date.available2024-09-25T19:44:14Z
dc.date.issued2010
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractMean platelet volume (MPV) is an indictor of platelet activation. Platelet activation and aggregation are central processes in the pathophysiology of coronary heart disease. Non-alcoholic fatty liver disease (NAFLD) is present up to onethird of the general population and the majority of patients with cardio-metabolic risk factors such as abdominal obesity, type 2 diabetes and other components of the metabolic syndrome (MS). The aim of the current study was to investigate the MPV in patients who had NAFLD. MPV values of the patients with NAFLD and of the patients without fatty liver disease were compared. NAFLD patients had significantly higher body mass index compared to the control cases. Among biochemical variables, fasting plasma glucose and triglyceride were significantly higher in the NAFLD group. NAFLD cases also had lower platelet count and higher MPV (10.43 ± 1.14 vs. 9.09 ± 1.25; p < 0.001, respectively). MPV was positively correlated with AST (r: 0.186, p < 0.042), ALT level (r: 0.279; p 0.002) and the presence of NAFLD (0.492; p < 0.001) but negatively correlated with platelet number (r: -0.26; p 0.004) and creatinine (r: -0.255; p 0.005). In logistic regression analysis (age, gender, NAFLD, body mass index, high-density lipid (HDL) cholesterol, systolic and diastolic blood pressure, triglyceride and fasting plasma glucose were used as covariates) only NAFLD was found to be the independent predictor of MPV (Odds Ratio (OR) 21.98) [95% confidence interval (CI): 2.404-201.048; p: 0.006]. We have shown for the first time in the literature that, patients with NAFLD have higher MPV. It may have prognostic value in NAFLD patients indicating a possible cardiovascular disease (CVD) risk increase. © 2010 Informa UK Ltd.en_US
dc.identifier.doi10.3109/09537100903391023
dc.identifier.endpage32en_US
dc.identifier.issn1369-1635
dc.identifier.issue1en_US
dc.identifier.pmid19947902en_US
dc.identifier.scopus2-s2.0-75449101587en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.3109/09537100903391023
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12731
dc.identifier.volume21en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofPlateletsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectMean platelet volumeen_US
dc.subjectNon-alcoholic fatty liver diseaseen_US
dc.titleMean platelet volume in patients with non-alcoholic fatty liver diseaseen_US
dc.typeArticleen_US

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