Administration of high dose intravitreal melatonin degenerates retinal cells in guinea pigs

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dc.authorid0000-0003-0887-6974
dc.authorid0000-0003-0887-6974
dc.authorid0000-0002-8781-8838
dc.contributor.authorYılmaz, Turgut
dc.contributor.authorNaziroǧlu, Mustafa
dc.contributor.authorÇelebi, Serdal
dc.contributor.authorÖzercan, Hanifi İbrahim
dc.contributor.authorKükner, A. Şahap
dc.date.accessioned2021-06-23T18:54:34Z
dc.date.available2021-06-23T18:54:34Z
dc.date.issued2004
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThe purpose of this study was to investigate the influence of intravitreally injected different doses of melatonin on retinal morphology. The right eyes of 35 male albino guinea pigs were used. The animals were classified randomly into five groups in equal numbers. First group was used as control and received intravitreal injection of placebo. Groups 2, 3, 4 and 5 received intravitreally injections of melatonin at 50, 100, 150 and 200 ?g/body weight (BW) each, respectively. The animals were sacrificed 15 days after the injections. The eyes were enucleated and processed for light microscopic evaluation.Intravitreal injection of melatonin at doses ranging from 50 to 150 ?g did not induce morphological changes, although a higher thickness of the inner plexiform layer (IPL) was found in Group 5 compared to other groups (p < 0.05). The mean retinal ganglion cell (RGC) counts were found to be lower in Group 5 compared to other groups (p < 0.05).Our findings indicate that intravitreal injection of melatonin at doses ranging from 50 to 150 ?g/BW does not induce morphological changes. The dose of 200 ?g/BW produced significant damage including retinal ganglion cell loss and formation of retinal edema. © 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.pathophys.2004.06.006
dc.identifier.endpage111en_US
dc.identifier.issn0928-4680
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-4444229343en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://doi.org/10.1016/j.pathophys.2004.06.006
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4493
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÇelebi, Serdal
dc.institutionauthorKükner, A. Şahap
dc.language.isoenen_US
dc.relation.ispartofPathophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHistologyen_US
dc.subjectIntravitreal Injectionen_US
dc.subjectMelatoninen_US
dc.subjectRetinaen_US
dc.titleAdministration of high dose intravitreal melatonin degenerates retinal cells in guinea pigsen_US
dc.typeArticleen_US

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