Comparison of demographical properties, Biochemical Parameters, Flow-mediated dilatation values and Carotis Intima Media Thickness of patients with Coronary Artery disease

To compare demographic characteristics, biochemical parameters, flow-mediated dilatation (FMD) values and carotid intima-media thickness (CIMT) between older (>45 years) and younger (<45 years) patients with coronary artery disease (CAD). Materials and Methods: The present study comprised a total of 114 patients divided into four groups. For the study groups, group 1 had 30 patients with CAD <45 years of age, and group 2 had 32 patients with CAD >45 years of age. Group 3 and group 4 were used as controls, comprising 28 (<45 years) and 24 (>45 years) healthy participants, respectively. Demographic characteristics, biochemical parameters, FMD values and CIMT were recorded and compared statistically among patients. Results: The median age of patients was 47.81±14.50 years. Hereditary risk factors and hyperlipidemia were statistically significant in group 1 than those in group 3. Likewise, fasting blood glucose levels and CIMT values were statistically higher in group 1 than those in group 3. Gender distribution and hyperlipidemia were statistically significant in group 2, in contrast to those in group 4. The values of FMD was lower in group 2 than those in group 4, which seemed to be statistically significant. The values of CIMT were higher whereas platelet counts were lower in group 2 than those in group 1, both findings of which were also statistically significant. The values of CIMT and Neutrophil/Lymphocyte (N/L) ratios increased whereas the values of FMD decreased significantly as the ages of participants increased. Conclusion: The factors where CAD was more common in subjects were as follows: being over 45 years of age (2.36 times), the presence of hyperlipidemia (3.58 times), increased N/L ratios (1.6 times), a combination of increased CIMT values and age (12 times), and decreased FMD values (2 times).