Is there any predictive capability of the first beta-HCG level in in vitro fertilization cycles

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dc.authorid0000-0003-2763-1665
dc.contributor.authorÖzkök, Beyza Ahlatçıoğlu
dc.contributor.authorYılmaz, Nurdane
dc.contributor.authorKarataş, Ahmet
dc.contributor.authorTokmak, Aslı
dc.contributor.authorÇavdar, Songül
dc.date.accessioned2021-06-23T19:43:10Z
dc.date.available2021-06-23T19:43:10Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: Presence of a marker that can predict pregnancy results in in-vitro fertilization cycles and the course of these pregnancies will be a stress mitigating factor for both doctors and the couples receiving treatment. This study was performed to assess whether serum ß-hCG level on the 13th day after embryo transfer (D13 ß-hCG) has a predictive role for different pregnancy results or not. DESIGN: Retrospective cohort study in a single tertiary center. MATERIALS AND METHODS: Two thousand two hundred thirty-six ICSI cycles were investigated. A total of 616 fresh, non-donor ICSI cycles who met the inclusion criteria were classified into two groups according to D13 ß-hCG; those R10 mIU/mL (pregnant¼251 cases) and those <10 mIU/mL (non pregnant¼365 cases). D13 ß¼hCG after embryo transfer were compared between the two groups and its predictive value for pregnancy outcomes was investigated. Mann-Whitney U test, Kruskal Wallis test, Pearson chi-square and fisher exact test were used, Post Hoc test was performed. ROC analysis and Spearman correlation were performed. A p value of p<0.05 was considered significant. RESULTS: Demographic cahracteristics and the number of embryos transferred were similar among groups with and without pregnancy (p>0.05). Among the 251 cases diagnosed with a pregnancy, 67 had miscarriages (55 early, 12 late). In singleton pregnancies; D13 ß-hCG levels was significantly lower in miscarriage group than ongoing pregnancy group (p<0.05). D13 ß hCG >127mIU/mL was found to predict that pregnancy will continue >20 weeks with a sensitivity of 83% and a specificity of 66.7% (PPV¼86.3% and NPV¼60%) (95% CI: 68%-84%, p<0,001). D13 ß-hCG <126mIU/mL could predict early miscarriage with 72% sensitivity and 82% spesificity (95% CI: 74%-89%) (p<0,001). D13 ß hCG levels could not predict preterm delivery either in single or multiple pregnancies (p¼0.552 and p¼0.426, respectively), and had no correlation with birth weight or gestational week at delivery (p¼0.102 and p¼0.571, respectively). CONCLUSIONS: According to this study live births were more frequent in patients with ß hCG >127.5 whereas early pregnancy loss was more likely below a ß-hCG level of 126.85. Levels above 319.5 could predict multiple pregnancy. No prediction for low birth weight or preterm birth could be made according to the ß hCG level. This is a retrospective analysis. Further prospective studies with more participants are required to predict early pregnancy outcomes in COH cycles.en_US
dc.identifier.doi10.1016/j.fertnstert.2016.07.528
dc.identifier.endpageE181en_US
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue3en_US
dc.identifier.startpageE181en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2016.07.528
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8711
dc.identifier.volume106en_US
dc.identifier.wosWOS:000449962500460en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorKarataş, Ahmet
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility And Sterilityen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFertilization Cyclesen_US
dc.subjectBeta-HCG LEVEL
dc.subjectICSI
dc.subjectROC Analysis
dc.titleIs there any predictive capability of the first beta-HCG level in in vitro fertilization cyclesen_US
dc.typeConference Objecten_US

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