Degradation of PLA, PLGA homo- and copolymers in the presence of serum albumin: a spectroscopic investigation

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dc.authorid0000-0003-2493-7570en_US
dc.authorid0000-0003-1256-0972
dc.contributor.authorÇatıker, Efkan
dc.contributor.authorGümüşderelioğlu, Menemşe
dc.contributor.authorGüner, Ali
dc.date.accessioned2021-06-23T19:17:19Z
dc.date.available2021-06-23T19:17:19Z
dc.date.issued2000
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.description.abstractPoly(D,L-lactide-co-glycolide) samples with different glycolide contents, ie 85:15, 75:25 and 50:50 mole ratios of lactide to glycolide, and poly(L-lactide) were obtained from a commercial source. Polymer films of 15 pm thickness were prepared by a solvent-casting method. Degradation studies were conducted at 37 degrees C in pH 7.4 phosphate buffered saline and in bovine serum albumin solution. The degradation behaviour of the films was followed by UV and FTIR spectrophotometry and viscometric and gravimetric measurements. Spectroscopic investigations showed that during the first month of degradation, both the chain length and the chain chemical structure changed, especially in the presence of bovine serum albumin. The short chains are attributed to the formation of new eater groups; however, the end-groups may be aldehyde- or ketone-like structures. While the intrinsic viscosities of all polymers decreased continuously after being exposed to the degradation media, insignificant mass loss occurred during the experimental investigation.en_US
dc.identifier.doi10.1002/1097-0126(200007)49:7<728
dc.identifier.endpage734en_US
dc.identifier.issn0959-8103
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-0034229458en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage728en_US
dc.identifier.urihttps://doi.org/10.1002/1097-0126(200007)49:7<728
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5351
dc.identifier.volume49en_US
dc.identifier.wosWOS:000088071900015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÇatıker, Efkan
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltden_US
dc.relation.ispartofPolymer Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDegradationen_US
dc.subjectSpectroscopyen_US
dc.subjectPoly(Lactide)en_US
dc.subjectPoly(Glycolide)en_US
dc.titleDegradation of PLA, PLGA homo- and copolymers in the presence of serum albumin: a spectroscopic investigationen_US
dc.typeArticleen_US

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