Cytomegalovirus antigenemia is observed more frequently following allogeneic peripheral blood stem cell transplantation compared to bone marrow transplantation

dc.authorid0000-0003-1797-8657
dc.contributor.authorÇelebi, Harika
dc.contributor.authorDalva, Klara
dc.contributor.authorÖzhan, Murat
dc.contributor.authorBeksaç, Meral
dc.date.accessioned2021-06-23T18:54:13Z
dc.date.available2021-06-23T18:54:13Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractOne of the major complications following hematopoietic stem cell transplantation (HSCT) is cytomegalovirus (CMV) infection. In our institution, three methods have been applied routinely for the diagnosis of CMV antigenemia (CMV-Ag): 1. Direct immunofluorescence microscopic (IFM) examination; 2. Flow cytometric (FC) analysis; and 3. Serological investigation. We were able to detect CMV-Ag by FC in 18 out of 75 transplanted cases. In 14 of these, positivity was confirmed by IFM as well. CMV-Ag was detected as positive by FC in samples from peripheral blood (14 cases) and/or bronchoalveolar lavage (BAL) fluid (4 cases). Eighteen patients had been transplanted [peripheral blood stem cell transplantation (PBSCT)/bone marrow transplantation (BMT): 16/2]. CMV-Ag was detected in 34% of PBSCTs and 7% of BMTs (p<0.008). Antigenemia was observed at a median of 4.5 months. In most of the patients, graft-versus-host disease (GVHD) was accompained by CMV-Ag. The ratio of acute GVHD/chronic GVHD was 6/10. Out of 18 CMV-Ag positive patients, 16 also had signs of infection. They were all positive by IFM as well. The two methods of CMV-Ag detection were correlated (r=0.619, p<0.0001). An important finding is the higher frequency of CMV-Ag and GVHD in patients who had received PBSCT. © Turkish Society of Hematology.en_US
dc.identifier.endpage110en_US
dc.identifier.issn1300-7777
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-33846162775en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage104en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4316
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33846162775&partnerID=40&md5=ce6ddf2c3362122d9590b151b327980f
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÇelebi, Harika
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCMV antigenemiaen_US
dc.subjectHematopoietic stem cell transplantationen_US
dc.titleCytomegalovirus antigenemia is observed more frequently following allogeneic peripheral blood stem cell transplantation compared to bone marrow transplantationen_US
dc.typeArticleen_US

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