Tissue Doppler echocardiography in evaluation of cardiac effects of subclinical hypothyroidism

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dc.contributor.authorArinc, H
dc.contributor.authorGunduz, H
dc.contributor.authorTamer, A
dc.contributor.authorSeyfeli, E
dc.contributor.authorKanat, M
dc.contributor.authorOzhan, H
dc.contributor.authorAkdemir, R
dc.date.accessioned2024-09-25T19:57:41Z
dc.date.available2024-09-25T19:57:41Z
dc.date.issued2006
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: Subclinical hypothyroidism (SH) is a mild form of thyroid failure, associated with initial signs of cardiovascular hypothyroidism. Tissue Doppler echocardiography (TDE) is a new and powerful method in evaluation of both regional and global systolic or diastolic ventricular function. We aimed to investigate the use of TDE in evaluation of cardiac effects of SH and affect of thyroid hormone replacement therapy (TRT) on tissue Doppler parameters of SH patients. Methods: Twenty-two patients who were diagnosed as SH and 22 healthy, age and sex-matched cases were included in the study. Conventional echocardiography and TDE were performed in all individuals. TRT was started in SH group. On the achievement of euthyroid state echocardiography were repeated. Results: Septal annulus relaxation time was significantly higher in SH group (82 +/- 21, 98 +/- 11 ms, p=0.024). Lateral annulus and myocardial relaxation times, precontraction/contraction ratios and precontraction times were also slightly higher. Septal lateral annulus and lateral myocardial relaxation times were decreased after TRT (98 +/- 11 vs. 81 +/- 12, p < 0.001, 89 +/- 14 vs. 78 +/- 11, p=0.022, 90 +/- 16 vs. 80 +/- 14 ms, p=0.008, respectively). Precontraction times and precontraction/contraction ratios decreased after TRT but did not reach the significance level. There was a positive correlation between TSH and TDE relaxation times. Conclusions: TDE is a powerful tool in diagnosis and follow-up of SH patients and TRT inhibits adverse affects of SH on myocardium. Septal myocardium is the most affected region of left ventricle in SH. The relaxation time is the best criteria of cardiac involvement and monitoring the effect of TRT.en_US
dc.identifier.doi10.1007/s10554-005-9030-2
dc.identifier.endpage186en_US
dc.identifier.issn1569-5794
dc.identifier.issn1573-0743
dc.identifier.issue2en_US
dc.identifier.pmid16265602en_US
dc.identifier.startpage177en_US
dc.identifier.urihttps://doi.org/10.1007/s10554-005-9030-2
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13552
dc.identifier.volume22en_US
dc.identifier.wosWOS:000236782700009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUyan, C
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Journal of Cardiovascular Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectechocardiographyen_US
dc.subjecthypothyroidismen_US
dc.subjectsubclinicalen_US
dc.subjecttissue Doppleren_US
dc.titleTissue Doppler echocardiography in evaluation of cardiac effects of subclinical hypothyroidismen_US
dc.typeArticleen_US

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