De Ritis score as an inflammatory marker in Hashimoto's thyroiditis

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dc.authorid0000-0002-3836-2125en_US
dc.authorid0000-0003-4201-9757en_US
dc.authorid0000-0001-7455-8136en_US
dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0001-8017-469Xen_US
dc.contributor.authorDuman, Tuba Taslamacıoğlu
dc.contributor.authorErge, Eray
dc.contributor.authorTel, Burçin Meryem Atak
dc.contributor.authorKızıltunç, Çağrı
dc.contributor.authorAktaş, Gülali
dc.date.accessioned2023-12-18T10:31:12Z
dc.date.available2023-12-18T10:31:12Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackgroundThe aim of the study was assessing the De Ritis score, an inflammatory marker, in Hashimoto's thyroiditis (HT) patients which is characterized with autoimmunity and chronic inflammation. MethodsBetween October 2021 and October 2022, the subjects in our outpatient clinics diagnosed with thyroiditis and healthy controls enrolled to the study. Age, gender, and laboratory parameters including C-reactive protein (CRP), alanine (ALT), and aspartate (AST) transaminases, thyroid stimulating hormone (TSH), free T4 (FT4), were obtained and recorded for all participants, retrospectively. Division of AST by ALT was the formula to calculate the De Ritis score. Characteristics and laboratory data of the study and healthy controls were compared. ResultsMedian de Ritis ratio of the HT group (1.11 (0.56)%) was significantly higher than that of the control group (0.91 (0.41)%), (p < .001). A positive and significant correlation between De Ritis score and CRP (r = 0.46, p < .001) values. ROC analysis revealed the sensitivity and the specificity of CRP in predicting HT were higher than those of the De Ritis score. A De Ritis score higher than 0.9% has 67% sensitivity and 50% specificity in selecting patients with thyroiditis (AUC: 0.69, p < .001, 95% CI: 0.63-0.76). ConclusionsWe think that elevated De Ritis score can be used as an adjunctive tool in the diagnosis of HT.en_US
dc.identifier.citationDuman, T. T., Erge, E., Tel, B. M. A., Kiziltunc, C., & Aktas, G. (2023). De Ritis score as an inflammatory marker in Hashimoto's thyroiditis. Precision Medical Sciences.en_US
dc.identifier.doi10.1002/prm2.12114
dc.identifier.endpage5en_US
dc.identifier.issn2642-2514
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1002/prm2.12114
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11900
dc.identifier.wosWOS:001004984200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorDuman, Tuba Taslamacıoğlu
dc.institutionauthorKızıltunç, Çağrı
dc.institutionauthorAktaş, Gülali
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPrecision Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutoimmune Thyroid Diseaseen_US
dc.subjectDe Ritis Scoreen_US
dc.subjectHashimoto's Thyroiditisen_US
dc.subjectAspartate-Aminotransferaseen_US
dc.subjectRatioen_US
dc.subjectAST/ALTen_US
dc.titleDe Ritis score as an inflammatory marker in Hashimoto's thyroiditisen_US
dc.typeArticleen_US

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