De Ritis score as an inflammatory marker in Hashimoto's thyroiditis
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
BackgroundThe aim of the study was assessing the De Ritis score, an inflammatory marker, in Hashimoto's thyroiditis (HT) patients which is characterized with autoimmunity and chronic inflammation. MethodsBetween October 2021 and October 2022, the subjects in our outpatient clinics diagnosed with thyroiditis and healthy controls enrolled to the study. Age, gender, and laboratory parameters including C-reactive protein (CRP), alanine (ALT), and aspartate (AST) transaminases, thyroid stimulating hormone (TSH), free T4 (FT4), were obtained and recorded for all participants, retrospectively. Division of AST by ALT was the formula to calculate the De Ritis score. Characteristics and laboratory data of the study and healthy controls were compared. ResultsMedian de Ritis ratio of the HT group (1.11 (0.56)%) was significantly higher than that of the control group (0.91 (0.41)%), (p < .001). A positive and significant correlation between De Ritis score and CRP (r = 0.46, p < .001) values. ROC analysis revealed the sensitivity and the specificity of CRP in predicting HT were higher than those of the De Ritis score. A De Ritis score higher than 0.9% has 67% sensitivity and 50% specificity in selecting patients with thyroiditis (AUC: 0.69, p < .001, 95% CI: 0.63-0.76). ConclusionsWe think that elevated De Ritis score can be used as an adjunctive tool in the diagnosis of HT.
Açıklama
Anahtar Kelimeler
Autoimmune Thyroid Disease, De Ritis Score, Hashimoto's Thyroiditis, Aspartate-Aminotransferase, Ratio, AST/ALT
Kaynak
Precision Medical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
Sayı
Künye
Duman, T. T., Erge, E., Tel, B. M. A., Kiziltunc, C., & Aktas, G. (2023). De Ritis score as an inflammatory marker in Hashimoto's thyroiditis. Precision Medical Sciences.
