Investigation of different interactions between Staphylococcus aureus phages and pomegranate peel, grape seed, and black cumin extracts

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dc.authorid0000-0002-5765-3884en_US
dc.authorid0000-0003-1333-060Xen_US
dc.authorid0000-0002-6639-4212
dc.authorid0000-0002-0385-6459
dc.contributor.authorTayyarcan, Emine Kübra
dc.contributor.authorSoykut, Esra Acar
dc.contributor.authorYılmaz, Özay Menteş
dc.contributor.authorBoyacı, İsmail Hakkı
dc.contributor.authorKhaaladi, Maha
dc.contributor.authorFattouch, Sarni
dc.date.accessioned2021-06-23T19:51:18Z
dc.date.available2021-06-23T19:51:18Z
dc.date.issued2019
dc.departmentBAİBÜ, Yeniçağa Yaşar Çelik Meslek Yüksekokulu, Gıda İşleme Bölümüen_US
dc.description.abstractToday, antibiotic resistance is one of the most crucial problems so that researchers have begun to search for alternatives to antibiotics. Among these alternatives, phage therapy and phytotherapy became prominent. The present study aims to put forward a different approach by combining these two methods. For this purpose, Staphylococcus aureus phages were isolated from commercial mixtures. After that, extraction of phenolic compounds from pomegranate peels (Ps), grape seeds (GSs), and black cumin (NS) was carried out and antimicrobial activities were determined. Phage-phenolic interactions were investigated by examining the effect of phenolic extracts on phage plaque sizes and then on phage titer and bacteria count. As a result, it was found that only the NS extract had a positive effect on phage activity and increased the size of phage plaques. However, no synergistic effect was observed in experiments performed in liquid media. It was also found that P and GS extracts inhibited phage activity. Practical Applications The present study was focused on effects of extracts obtained from pomegranate peel, grape seed, and black cumin on Staphylococcus aureus phage activity. It is known that antibiotic resistance constitutes a major obstacle to the pathogen elimination. In this study, phage therapy and phytotherapy, which are prominent methods in pathogen elimination, have been combined and the effect of phenolic compounds isolated from natural sources on phage activity and bacteria count have been examined. Given the results of the current study, it has been demonstrated that the combined use of phages and antimicrobial compounds could be an important alternative to combating pathogens. It is thought that this combined method should be taken into consideration both in the practice of phage therapy on humans and animals, and in applications in the food industry.en_US
dc.identifier.doi10.1111/jfs.12679
dc.identifier.issn0149-6085
dc.identifier.issn1745-4565
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85068666854en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/jfs.12679
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9961
dc.identifier.volume39en_US
dc.identifier.wosWOS:000479594600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorSoykut, Esra Acar
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Food Safetyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhage-Bacteriaen_US
dc.subjectMOI
dc.titleInvestigation of different interactions between Staphylococcus aureus phages and pomegranate peel, grape seed, and black cumin extractsen_US
dc.typeArticleen_US

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