The effect of NF-kappa B and angiotensin II on the proliferation in human breast adenocancer cell line

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dc.authorid0000-0002-3060-1507
dc.authorid0000-0003-0290-5498
dc.contributor.authorÖzünal, Zeynep Güneş
dc.contributor.authorBayram, Recep
dc.contributor.authorYavuz, Muhsine Zeynep
dc.contributor.authorUcbek, Ali
dc.contributor.authorAydoğar, A.
dc.contributor.authorUzun, Özge
dc.contributor.authorGepdíremen, Akçahan Akçahan
dc.date.accessioned2021-06-23T18:55:46Z
dc.date.available2021-06-23T18:55:46Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThere are many in-vitro studies implicating that Angiotensin (Ang)II stimulates solid organ cancer growth. Effect of AngII on cell proliferation can be related to nuclear factor NFkB. The aim of the present study is to examine the effects of pyrithione, an NFkB inhibitor and AngII on breast cancer cell proliferation. MCF-7 is treated with AII (10?M) and NFkB inhibitor, pyrithione sodium (0,1-100?M). Cells are counted and photographed. WST-1 is used to measure viability in 48h after treatment and groups are fluorescent dyed with ethidium bromide. The results of cell count showed that cell proliferation was increased in AngII treated group when compared with control group. However, this increase did not show statistically significance. Cell count was decreased in pyrithione (10 and 100?M) treated group. Morphologic changes were most apparent in 100?M pyrithione group. We concluded that pyrithione alone or in combination with AngII decreased MCF-7 cell proliferation.en_US
dc.identifier.endpage416en_US
dc.identifier.issn0975-8585
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84891096931en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage411en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4855
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84891096931&partnerID=40&md5=87e1b90d267162aa98f7582c34c6c54f
dc.identifier.volume4en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBayram, Recep
dc.institutionauthorYavuz, Muhsine Zeynep
dc.institutionauthorUcbek, Ali
dc.institutionauthorAydoğar, A.
dc.institutionauthorUzun, Özge
dc.institutionauthorGepdíremen, Akçahan Akçahan
dc.language.isoenen_US
dc.relation.ispartofResearch Journal of Pharmaceutical, Biological and Chemical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngIIen_US
dc.subjectMCF-7 Cell Lineen_US
dc.subjectNFkBen_US
dc.subjectPyrithioneen_US
dc.titleThe effect of NF-kappa B and angiotensin II on the proliferation in human breast adenocancer cell lineen_US
dc.typeArticleen_US

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