The effect of enteral glutamine on adaptation process in short bowel syndrome induced rats through small intestinal resection of varied length

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dc.authorid0000-0001-5608-5742
dc.authorid0000-0002-1162-5140
dc.contributor.authorGedik, Şenol
dc.contributor.authorOtçu, Selçuk
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorÖnen, Abdurrahman
dc.date.accessioned2021-06-23T18:54:14Z
dc.date.available2021-06-23T18:54:14Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: The purpose of the study was to determine the effect of glutamine on adaptation process in short bowel syndrome (SBS) induced rats through small intestinal resection of varied length. Material and Method: A total of 35 rats were used in this study. Laparotomy alone was performed in group 1 rats (sham). Short bowel syndrome was induced by performing small intestinal resection of 65% in groups 2 and 3, and 85% in groups 4 and 5. Glutamine was orally administered at a dose of 2.5 g/kg/day in groups 3 and 5 for 21 days. The rats were followed-up in terms of weight, and small intestinal biopsies were taken at the end of the study. Results: Significant diarrhea and weight loss developed in SBS induced rats between days 1-6 (p<0.05). Weight gain after 18th day of glutamine administration was significantly higher in group 3 compared to groups 2 and 4. In terms of villus height, crypt depth, mucosal thickness and mitosis count, there was a significant difference between group 3 and other groups in which resection alone was performed (groups 2 and 4). Conclusions: In group 3 rats undergone less small bowel resection, we think that intestinal adaptation develops better in the remaining bowel due to the effect of glutamine.en_US
dc.identifier.endpage74en_US
dc.identifier.issn1305-5194
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-33748436801en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4328
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33748436801&partnerID=40&md5=fe25482863a062049566ca1f9cfeb313
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÖztürk, Hayrettin
dc.institutionauthorKilinç, Nihal
dc.institutionauthorDokucu, Ali Ihsan
dc.institutionauthorÖnen, Abdurrahman
dc.language.isotren_US
dc.relation.ispartofCocuk Cerrahisi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdaptationen_US
dc.subjectGlutamineen_US
dc.subjectShort Bowel Syndromeen_US
dc.titleThe effect of enteral glutamine on adaptation process in short bowel syndrome induced rats through small intestinal resection of varied lengthen_US
dc.title.alternativeFarklı uzunluktaki incebarsak rezeksiyonu ile kısa barsak sendromu oluşturulan sıçanlarda enteral glutaminin adaptasyona etkisien_US
dc.typeArticleen_US

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