Does Eta Protein Differentiate Rheumatoid Arthritis from Psoriatic Arthritis?

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dc.authorscopusid57540146100
dc.authorscopusid58318135600
dc.authorscopusid23571265400
dc.authorscopusid56320908200
dc.authorscopusid57428388300
dc.authorscopusid57203004737
dc.authorscopusid16401758300
dc.contributor.authorKor, Ahmet
dc.contributor.authorOrhan, Kevser
dc.contributor.authorMaraş, Yüksel
dc.contributor.authorOğuz, Esra Fırat
dc.contributor.authorUnan, Mehtap Kalçık
dc.contributor.authorDilek, Gamze
dc.contributor.authorErten, Şükran
dc.date.accessioned2024-09-25T19:43:06Z
dc.date.available2024-09-25T19:43:06Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAim: The clinical symptoms and laboratory markers of Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) can be very similar, so making a differential diagnosis between these two diseases is often difficult. Serological parameters to be used in differential diagnosis can guide the clinician. This study aimed to investigate the usability of 14-3-3? (eta) protein as a biomarker in the differential diagnosis of PsA and RA, and the relationships between eta protein and disease activity scores and joint erosions in PsA and RA. Methods: 54 PsA patients, 53 RA patients, and 56 healthy individuals were included in this study. The ELISA (Enzyme-Linked ImunoSorbent Assay) kit was used as a quantitative sandwich enzyme immunoassay technique to detect human eta protein levels. Receiver-operating Characteristic (ROC) curves analysis was used to determine the sensitivity and specificity of the eta protein. Results: Eta protein levels were found to be significantly higher in the RA group than in the PsA [B:-0.341, OR (95% CI): 0.711 (0.556-0.909), p: 0.007] and control [B:-0.225, OR (95% CI): 0.798 (0.641-0.995), p: 0.045] groups. Eta protein median values were significantly higher in patients with joint erosion than in those without [?= 0.151, OR (95% CI): 1.163 (1.003-1.349), p: 0.046]. Conclusion: Eta protein levels are higher in the serum of RA patients than PsA and are associated with joint erosion. Eta protein may be a potential biomarker in the differential diagnosis of RA and PsA. It may represent a possible therapeutic step in the pathophysiological pathways in the development of joint erosion. © 2024 Bentham Science Publishers.en_US
dc.description.sponsorshipTurkish Rheumatology Association, (2023/015)en_US
dc.identifier.doi10.2174/0109298673295359240422115759
dc.identifier.endpage6520en_US
dc.identifier.issn0929-8673
dc.identifier.issue39en_US
dc.identifier.pmid38685775en_US
dc.identifier.scopus2-s2.0-85200970629en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage6510en_US
dc.identifier.urihttps://doi.org/10.2174/0109298673295359240422115759
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12433
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publishersen_US
dc.relation.ispartofCurrent Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subject14-3-3? proteinen_US
dc.subjectdisease activityen_US
dc.subjectjoint erosionen_US
dc.subjectpsoriatic arthritisen_US
dc.subjectrheumatoid arthritisen_US
dc.subjectvisual analog scaleen_US
dc.titleDoes Eta Protein Differentiate Rheumatoid Arthritis from Psoriatic Arthritis?en_US
dc.typeArticleen_US

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