Protective effects of pinocembrin and pinostrobin against hydrogen peroxide-induced stress in retina pigment epithelial cells

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dc.authorid0000-0003-2940-3172
dc.contributor.authorKılıçaslan, Derya
dc.contributor.authorKurt, Akif Hakan
dc.contributor.authorDoğaner, Adem
dc.date.accessioned2021-06-23T19:53:50Z
dc.date.available2021-06-23T19:53:50Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThis work was aimed at examining the protective effect of pinocembrin and pinostrobin in retinal pigment epithelial cells exposed to oxidative stress caused by hydrogen peroxide (H2O2). In the present study, the ARPE-19 cell line, one of the retinal pigment epithelial cell lines, was selected as the test cell culture. The incubation was performed on the basis of a 16-h application time of 500 mu MH2O2 to induce the oxidative stress damage in the ARPE-19 cell line. The protective effect of applying pinocembrin and pinostrobin in H2O2-induced oxidative damage was evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The obtained results showed evidence of therapeutic effects of pinocembrin and pinostrobin in cells exposed to oxidative stress-induced damage. Pinocembrin and pinostrobin can find direct medical application as pharmaceutical agents and may contribute to the design, synthesis and semi-synthesis of new drugs and to the development of chemical templates for treatment of diseases.en_US
dc.identifier.doi10.1007/s11094-020-02275-y
dc.identifier.endpage796en_US
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85096328257en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage788en_US
dc.identifier.urihttps://doi.org/10.1007/s11094-020-02275-y
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10282
dc.identifier.volume54en_US
dc.identifier.wosWOS:000590995600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKurt, Akif Hakan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPinocembrinen_US
dc.subjectPinostrobinen_US
dc.subjectOxidative Stressen_US
dc.subjectCell Viabilityen_US
dc.subjectARPE-19en_US
dc.titleProtective effects of pinocembrin and pinostrobin against hydrogen peroxide-induced stress in retina pigment epithelial cellsen_US
dc.typeArticleen_US

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