Effect of the combination of glibenclamide, an ATP-dependent potassium channel blocker, and metoprolol, a cardioselective ?-adrenoceptor blocker, during myocardial infarction in conscious rats

Basit Öğe Kaydı
dc.authorid0000-0001-5073-0691
dc.contributor.authorBozdoğan, Ömer
dc.contributor.authorLepran, Istvan
dc.contributor.authorPapp, Julius Gy.
dc.date.accessioned2021-06-23T18:40:22Z
dc.date.available2021-06-23T18:40:22Z
dc.date.issued2000
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractWe investigated the possible interaction of glibenclamide and metoprolol on the occurrence of life threatening arrhythmias during the acute phase of experimental myocardial infarction. Coronary artery ligation was performed in conscious rats and ECG was recorded for 15 min following ligation. Neither metoprolol (2 mg/kg i.p., 20 min before coronary artery ligation), nor glibenclamide (5 mg/kg i.p., 30 min before ligation) pretreatment increased significantly the survival rate during the acute phase of myocardial infarction (10 % and 22 %, respectively vs. 9 % in controls). Combination of glibenclamide with metoprolol, however, significantly improved the survival rate (62 %, P < 0.05). These results suggest that the combination of a cardioselective β-blocking agent with an ATP dependent potassium channel inhibitor may result in an enhanced antiarrhythmic effect during the acute phase of myocardial infarction.en_US
dc.identifier.endpage522en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-0033740042en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage517en_US
dc.identifier.trdizinidTR-DizinIDen_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TVRJM01UZzQ
dc.identifier.urihttps://hdl.handle.net/20.500.12491/3076
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorBozdoğan, Ömer
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlibenclamideen_US
dc.subjectMetoprolol
dc.subjectArrhythmias
dc.subjectSudden Cardiac Death
dc.subjectConscious Rats
dc.titleEffect of the combination of glibenclamide, an ATP-dependent potassium channel blocker, and metoprolol, a cardioselective ?-adrenoceptor blocker, during myocardial infarction in conscious ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
omer-bozdogan-3076.pdf
Boyut:
55.13 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin / Full text
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu
Biyoloji Bölümü Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu