From adipose tissue protein secretion to adipopharmacology of disease

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dc.authorid0000-0001-5912-9392
dc.contributor.authorTöre, Fatma
dc.contributor.authorTonchev A.B.
dc.contributor.authorFiore M.
dc.contributor.authorTunçel N.
dc.contributor.authorAtanassova P.
dc.date.accessioned2021-06-23T18:54:10Z
dc.date.available2021-06-23T18:54:10Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAn extensive research in the last few years has identified about hundred adipose tissue-secreted proteins, named adipokines or adipocytokines. However, our knowledge of the structures and molecules involved in the intracellular secretory pathway (synthesis, translocation, folding, targeting, sorting, storage, and exocytosis) of adipokines is at present limited. Relatively more is known about insulin-responsive trafficking of glucose transporters (GLUTs). Adipokines have multiple biological functions beyond lipid and carbohydrate metabolism, whereas GLUT4 is the major glucose transporter of adipocytes and skeletal muscles. Adipokines play an important role in the pathogenesis of a wide variety of diseases, and dysregulation of GLUT4 transport is implicated in insulin resistance and related disorders. Conceptually, adipobiology of disease has emerged as a novel field of studies in basic and clinical medicine. Here we present a state-of-the-science on some aspects of these studies with a special reference to the intracellular secretory pathway, focusing on adiponectin, GLUT4, and nerve growth factor (NGF), and suggesting that each step of this pathway may be a potential drug target. Given the beneficial effects of adiponectin, NGF and GLUT4 on various metabolic, vascular and inflammatory processes, a hypothesis of metabotrophic factor deficit in the pathogenesis of adipose-linked diseases is discussed. Adipopharmacological evaluation of this hypothesis may provide novel targets for drug development. © 2007 Bentham Science Publishers Ltd.en_US
dc.identifier.doi10.2174/187152207780363712
dc.identifier.endpage155en_US
dc.identifier.issn1871-5222
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-34247599387en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage149en_US
dc.identifier.urihttps://doi.org/10.2174/187152207780363712
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4283
dc.identifier.volume7en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTöre, Fatma
dc.language.isoenen_US
dc.relation.ispartofImmunology, Endocrine and Metabolic Agents in Medicinal Chemistryen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdipobiologyen_US
dc.subjectAdiponectinen_US
dc.subjectDrugsen_US
dc.subjectEndoplasmic reticulumen_US
dc.subjectGLUT4en_US
dc.subjectMetabotrophic Factorsen_US
dc.subjectMicrotubulesen_US
dc.subjectNGFen_US
dc.titleFrom adipose tissue protein secretion to adipopharmacology of diseaseen_US
dc.typeReview Articleen_US

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