Protective role of alpha-tocopherol on retinal injury in experimental uveitis in guinea pigs

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dc.contributor.authorDemir, Dilek
dc.contributor.authorYılmaz, Turgut
dc.contributor.authorİlhan, Nevin
dc.contributor.authorYekeler, Hayrettin
dc.contributor.authorAydemir, Orhan
dc.contributor.authorKükner, A.Sahap
dc.date.accessioned2021-06-23T18:54:16Z
dc.date.available2021-06-23T18:54:16Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: Purposeof the study was to determine whether alpha-tocopherol (AT) can protect the retina from oxidative damage in experimental uveitis (EU). Material and Methods: The eyes of 36 adult male guinea pigs were studied. The guinea pigs were divided into three groups of 12 animals each. The first group was used as control. The right eyes of groups 2 and 3 received an intravitreal injection of bovine serum albumin for EU induction. At the same time and also on the consecutive third and fifth days, group 3 received intraperitoneal AT injections. The samples were collected on the eighth day. Retinal malondialdehyde (MDA) levels and the average thickness of the inner plexiform layer were measured and the histopathology of the eyes was studied. Results: The MDA level was significantly lower in the control group than in the groups 2 (p < 0.01) and 3 (p < 0.05). When compared with the EU group 2, there was a significant lowering of MDA in the AT injected group 3 (p < 0.01). The thickness of the inner plexiform layer in the control group 1 was significantly lower than in the other groups (p < 0.01). Its thickness in the group 3 supplied with AT was significantly lower than in the group 2 (p < 0.01). Conclusions: The data indicate that intraperitoneal AT administration protects against EU injury in the guinea pig retina as evidenced by the reduced MDA and the thickness of retina. © 2006 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.pathophys.2005.12.002
dc.identifier.endpage79en_US
dc.identifier.issn0928-4680
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-33748701645en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://doi.org/10.1016/j.pathophys.2005.12.002
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4348
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKükner, Aysel Şahap
dc.language.isoenen_US
dc.relation.ispartofPathophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha-tocopherolen_US
dc.subjectExperimental Uveitisen_US
dc.subjectLipid Peroxidationen_US
dc.subjectRetinaen_US
dc.titleProtective role of alpha-tocopherol on retinal injury in experimental uveitis in guinea pigsen_US
dc.typeArticleen_US

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