A silver nanoparticles-catalyzed efficient three-component synthesis of polysubstituted 4h-chromenylphosphonates and their antioxidant activity
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A simple and efficient protocol for one-pot three-component synthesis of structurally diverse dialkyl 2-amino-3-cyano-4H-chromen-4-ylphosphonates from the condensation of salicylaldehydes, malononitrile, and trialkyl phosphite using silver nanoparticles as catalyst in ethanol at reflux has been developed. Selected new compounds were evaluated for their antioxidant activity by free radical screening using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Among the compounds employed, 5a, 5b, and 5h showed promising DPPH radical scavenging activities compared to the experimental standards at low concentration (100 mu g/mL) after 24h incubation. [GRAPHICS] .
Açıklama
Anahtar Kelimeler
Antioxidant Activity, Dialkyl 2-Amino-3-Cyano-4H-Chromen-4-Ylphosphonates, Multicomponent Reaction, Nanocatalyst, Silver Nanoparticles
Kaynak
Synthetic Communications
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
48
Sayı
18
