The relationship of pentraxin-3 levels with IL-17, fetuin-A, insulin in patients with Behcet's disease

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dc.authorid0000-0003-0411-9669en_US
dc.authorid0000-0001-5299-7250
dc.authorid0000-0003-4178-8730
dc.contributor.authorSağ, Sinem
dc.contributor.authorKamanlı, Ayhan
dc.contributor.authorAltındiş, Mustafa
dc.contributor.authorSağ, Mustafa Serdar
dc.contributor.authorHarman, Halil
dc.date.accessioned2021-06-23T19:45:06Z
dc.date.available2021-06-23T19:45:06Z
dc.date.issued2017
dc.departmentBAİBÜ, Sağlık Bilimleri Fakültesi, Fizyoterapi ve Rehabilitasyon Bölümüen_US
dc.description.abstractBackground: Pentraxin (PTX) 3 is synthesized by leukocytes, dendritic cells, endothelial cells and monocytes in response to IL-1 and tumor necrosis factor (TNF)-alpha, and it might be informative regarding local inflammation. In additionally, pentraxin (PTX)-3, produced by endothelial cells in atherosclerotic plaques, acts as amodulator of inflammatory processes and is involved in the development of atherosclerotic lesions. Objective: This study aimed to identify the levels of proteins, such as PTX and fetuin-A, which are thought to play a role in the progression of atherosclerotic and cardiovascular disorders in patients with BD, and to investigate the relationship of these protein levels with BD activity, inflammatory cytokines, insulin resistance and dyslipidaemia. Patients and methods: This study included 58 patients (36 females, 22 males) with BD and 20 healthy controls. Serum PTX-3, fetuin-A, interleukin (IL)-17 and insulin concentrations were determined. Homeostasis model of insulin resistance (HOMA-IR) values were calculated, and disease activity was assessed using BD Current Activity Form (BDCAF) scores. Results: The levels pentraxin-3, fetuin-A, IL-17, insulin and HOMA-IR in patients with BD were found to be higher than control subjects (p < 0.05). PTX-3 and fetuin-A levels showed no correlation with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), or scores on the various BDCAF domains. IL-17 levels were significantly positively correlated with the BDCAF arthritis score. No significant relationships were identified between the lipid profile and PTX-3, IL-17 or fetuin-A levels. No correlations were found among PTX, IL-17, fetuin-A, and insulin and HOMA-IR levels (p > 0.05). Conclusions: Similar to CRP, PTX-3 is an acute-phase reactant that is considered an inflammatory and atherosclerotic biomarker. This study showed that PTX-3 levels can increase, similar to IL-17, but no relationship was detected between disease activity and coronary risk factors such as serum lipids, glucose intolerance and obesity. This was a cross-sectional study; therefore, the patients should be followed in long-term studies to determine whether higher PTX levels in BD patients are associated with a higher incidence of cardiovascular disease. Copyright (C) 2017, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC.en_US
dc.identifier.doi10.1016/j.dsi.2017.06.003
dc.identifier.endpage200en_US
dc.identifier.issn1027-8117
dc.identifier.issn2223-330X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85028080009en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage195en_US
dc.identifier.urihttps://doi.org/10.1016/j.dsi.2017.06.003
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9098
dc.identifier.volume35en_US
dc.identifier.wosWOS:000415388900005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorHarman, Halil
dc.language.isoenen_US
dc.publisherElsevier Taiwanen_US
dc.relation.ispartofDermatologica Sinicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBehcet Diseaseen_US
dc.subjectPentraxin-3en_US
dc.subjectAtherosclerosisen_US
dc.titleThe relationship of pentraxin-3 levels with IL-17, fetuin-A, insulin in patients with Behcet's diseaseen_US
dc.typeArticleen_US

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