Bone induction capacity of the periosteum and neonatal dura in the setting of the rat zygomatic arch fracture model

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dc.authorid0000-0002-7705-7510
dc.contributor.authorÖzçelik, Derya
dc.contributor.authorTuran, Tuğrul
dc.contributor.authorKabukcuoǧlu, Fevziye
dc.contributor.authorUğurlu, Kemal
dc.contributor.authorÖztürk, Özcan
dc.date.accessioned2021-06-23T18:54:46Z
dc.date.available2021-06-23T18:54:46Z
dc.date.issued2003
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: Osteogenic properties of the dura and periosteum are thought to contribute to the regenerative capacity of membranous bone tissue. The purpose of this investigation was to elucidate (1) whether dura without underlying neural tissues can induce osteogenesis, (2)to what extent the periosteum participates in membranous bone healing, and (3) the difference between durainduced and periosteum-induced osteogenesis. Methods: A standardized 2-mm defect was created within the middle portion of each zygomatic arch in 30 Wistar albino rats. The rats were divided into 3 groups, 10 animals in each group. In group 1, the periosteum was removed and neonatal dura grafts were transplanted onto the zygomatic arch bone defect circumferentially. In group 2, the overlying periosteum was preserved. In group 3, the periosteum was removed. At 3 and 10 weeks, animals from each group were killed, and specimens were obtained. Data were collected from the 3-dimensional computed tomographic scans and histologic studies to compare the extent of bony repair. Results: Fracture sites demonstrated osteogenesis associated with chondrogenesis in groups 1 and 2 and only limited osteogenesis with no chondrogenesis in group 3. In some animals in group 3, cortical bone ends underwent resorption. In groups 1 and 2, bone defects were obliterated by the formation of the mature compact bone at 10 weeks postoperatively. The difference between bone regeneration in these groups was not significant (P=.16). In group 3, the defects failed to heal by bony union, and in most of the samples the fibrous union was observed instead. The difference between groups 1 and 3 was significant (P=.03). The difference between groups 2 and 3 was not significant (P=.09). Conclusions: The trend toward significance is in agreement with the current clinical practice of preserving periosteum in the manipulations of the membranous bone defects. Newborn dura can exert a potentiating effect on osteogenesis. © 2003 American Medical Association. All rights reserved.en_US
dc.identifier.doi10.1001/archfaci.5.4.301
dc.identifier.endpage308en_US
dc.identifier.issn1521-2491
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-7044265318en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage301en_US
dc.identifier.urihttps://doi.org/10.1001/archfaci.5.4.301
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4568
dc.identifier.volume5en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÖztürk, Özcan
dc.language.isoenen_US
dc.publisherAmerican Medical Associationen_US
dc.relation.ispartofArchives of Facial Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone Induction Capacityen_US
dc.subjectRat Zygomatic
dc.titleBone induction capacity of the periosteum and neonatal dura in the setting of the rat zygomatic arch fracture modelen_US
dc.typeArticleen_US

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