Green one-pot multicomponent synthesis, biological evaluation and theoretical investigations of some novel beta-acetamido ketone derivatives as potent cholinesterase inhibitors

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dc.authorid0000-0002-7727-8583en_US
dc.authorid0000-0003-2933-5296
dc.contributor.authorChibane, Adil Ziadi
dc.contributor.authorBoulcina, Raouf
dc.contributor.authorBoulebd, Houssem
dc.contributor.authorBensouici, Chawki
dc.contributor.authorYıldırım, Muhammet
dc.contributor.authorDebache, Abdelmadjid
dc.date.accessioned2021-06-23T19:54:09Z
dc.date.available2021-06-23T19:54:09Z
dc.date.issued2020
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.description.abstractA series of novel beta-acetamido ketones have been prepared via a four-component condensation between aromatic aldehydes, enolizable ketones, acyl chloride and acetonitrile in the presence of 10 mol% of phenylboronic acid as a catalyst. The expected products have been obtained in good to excellent yields. In addition, in vitro cholinesterase inhibitory activity of title compounds has been studied and the results indicated that some compounds exhibited remarkable BChE activity. In order to gain insights into the molecular structure and chemical reactivity of the synthesized beta-acetamido ketones, density functional theory (DFT) calculations were also carried out. (C) 2020 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.tet.2020.131260
dc.identifier.issn0040-4020
dc.identifier.issue25en_US
dc.identifier.scopus2-s2.0-85084795206en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.tet.2020.131260
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10439
dc.identifier.volume76en_US
dc.identifier.wosWOS:000537426700008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYıldırım, Muhammet
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTetrahedronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMulticomponent Reactionen_US
dc.subjectPhenylboronic Aciden_US
dc.subjectBeta-Acetamido Ketonesen_US
dc.subjectCholinesterase Inhibitoryen_US
dc.subjectDFT Calculationsen_US
dc.titleGreen one-pot multicomponent synthesis, biological evaluation and theoretical investigations of some novel beta-acetamido ketone derivatives as potent cholinesterase inhibitorsen_US
dc.typeArticleen_US

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