Phenolic characterization, antimutagenic, antioxidant and antibacterial capacities of seven endemic Dianthus species from Turkey

Basit Öğe Kaydı
dc.authoridCelik, Ayse/0009-0002-8232-5265
dc.authoridBABA, Yavuz/0000-0001-5311-9513
dc.contributor.authorCelik, Ayse Kaya
dc.contributor.authorUsta, Necibe Canan
dc.contributor.authorBaba, Yavuz
dc.contributor.authorCimen, Ayca
dc.contributor.authorTurker, Arzu Ucar
dc.date.accessioned2024-09-25T19:56:21Z
dc.date.available2024-09-25T19:56:21Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractDianthus genus, belonging to the family Caryophyllaceae, encompasses over 300 species. Various Dianthus spp. have long been utilized in traditional medicine for the treatment of a wide range of conditions including chronic pain, urinary infections, carbuncles, menostasis, gonorrhea, cough, liver diseases, and certain types of cancer. The objective of this study was to determine the biological activities (antimutagenicity, antibacterial and antioxidant), total phenol-flavonoid content and individual phenolic constituents of methanolic extracts of two different parts [FC (flower+capitulum) and LS (leaf+stem)] of seven different endemic Dian-thus spp. (D. ancyrensis, D. aticii, D. balansae, D. carmelitarum, D. kastembeluensis, D. lydus and D. leucophaeus) found in Bolu, Turkey. In the antimutagenicity tests, D. carmelitarum, D. ancyrensis. D. kastembeluensis and D. lydus demonstrated higher inhibition effect against the mutagenic activity of sodium azide (NaN3) and 4-nitro-o-phenylene diamine (NPD) on Salmonella typhimurium TA 100 and TA 98 strains, respectively. D. carmelitarum-LS displayed the highest antimutagenic effect against the mutagen (base-substitution) on the TA 100 strain, while D. carmelitarum-FC exhibited the highest inhibition against mutagenic activity (frame-shift mutagenesis) by 4-nitro-o-phenylene diamine (NPD) on S. typhimurium TA98 strain. Among the tested 17 bacteria, only 4 bacteria (Staphylococcus epidermidis, S. aureus, Streptococcus pyogenes and Klebsiella pneumonia) demonstrated sensitivity to five different Dianthus spp. D. leucophaeus exhibited moderate antibacterial activity against S. epidermidis. Furthermore, S. pyogenes was quite susceptible to D. kastembeluensis, D. aticii and D. lydus. The most powerful radical scavenging activity was observed with D. balansae-LS. Consistent with this result, D. balansae-LS showed the highest total phenolic content. D. aticii-LS had the highest content of total flavonoid. U-HPLC analysis revealed that rutin, phloridzin, ferulic acid and chlorogenic acid were the most dominant compounds in endemic Dianthus spp. These findings highlight the potential of these plants as valuable natural sources for pharmaceutical and nutraceutical applications.(c) 2023 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University Research Foundation [BAP 2023-TYL-6.12-0003]en_US
dc.description.sponsorshipThis study was supported by Bolu Abant Izzet Baysal University Research Foundation (BAP 2023-TYL-6.12-0003) , Turkey.en_US
dc.identifier.doi10.1016/j.sajb.2023.11.032
dc.identifier.endpage49en_US
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.scopus2-s2.0-85179051971en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2023.11.032
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13237
dc.identifier.volume164en_US
dc.identifier.wosWOS:001129932800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAntibacterialen_US
dc.subjectAntimutagenicen_US
dc.subjectAntioxidanten_US
dc.subjectDianthusen_US
dc.subjectEndemicen_US
dc.subjectFlavonoiden_US
dc.subjectHPCLen_US
dc.subjectPhenolen_US
dc.titlePhenolic characterization, antimutagenic, antioxidant and antibacterial capacities of seven endemic Dianthus species from Turkeyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu