Separation of D,L-Ampicillin by ligand exchange-micellar electrokinetic chromatography

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dc.authorid0000-0002-6672-6862en_US
dc.authorid0000-0003-3260-1639
dc.contributor.authorSarı, Duygu
dc.contributor.authorDerazshamshir, Ali
dc.contributor.authorAşır, Süleyman
dc.contributor.authorGöktürk, Ilgım
dc.contributor.authorYılmaz, Fatma
dc.contributor.authorDenizli, Adil
dc.date.accessioned2021-06-23T19:50:25Z
dc.date.available2021-06-23T19:50:25Z
dc.date.issued2019
dc.departmentBAİBÜ, Gerede Meslek Yüksekokulu, Kimya Ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.description.abstractIn this study, D,L-ampicillin separation was carried out by ligand exchange-micellar electrokinetic chromatography method using L-Lysine monohydrochloride as a ligand and copper (II) sulfate pentahydrate is a central ion supplier. Isomeric separations were performed using capillary electrophoresis (CE) instrument, in which SDS-L-Lys-Cu+2 micelle complex was used as a pseudostationary phase. The effect of pH, SDS amount, applied electrical field, pressure, organic solvent ratio and ampicillin D,L-ratios were investigated. Fast,inexpensive and sensitive approach for the simultaneous separation of D,L-ampicillin in both aqueous and real antibiotic sample was performed using CE coupled with UV detector. The separation was achieved in a short period of 7 minutes with high-sensitivity andlow-detection limit of 1.25 mu M by the developed SDS-L-Lys-Cu+2 micelle-chiral selector complexes without using any extra process such as imprinting or spacer arms for the immobilization of the ligands.en_US
dc.identifier.doi10.33263/BRIAC96.522533
dc.identifier.endpage4533en_US
dc.identifier.issn2069-5837
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85075714682en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage4522en_US
dc.identifier.urihttps://doi.org/10.33263/BRIAC96.522533
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9778
dc.identifier.volume9en_US
dc.identifier.wosWOS:000503065300011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYılmaz, Fatma
dc.language.isoenen_US
dc.publisherBiointerface Research Applied Chemistryen_US
dc.relation.ispartofBiointerface Research In Applied Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmpicillinen_US
dc.subjectCapillary Electrophoresisen_US
dc.subjectMicelleen_US
dc.titleSeparation of D,L-Ampicillin by ligand exchange-micellar electrokinetic chromatographyen_US
dc.typeArticleen_US

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