Nimodipine aggravates systemic kainic acid toxicity in retinal ganglion cells of intact mice

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dc.authorid0000-0001-5544-8548
dc.authorid0000-0003-0587-4383
dc.authorid0000-0002-4776-2630
dc.authorid0000-0002-9122-6755
dc.contributor.authorGepdiremen, Akçahan Akçahan
dc.contributor.authorKaya, Murat
dc.contributor.authorKoçer, İbrahim
dc.contributor.authorGündoğdu, Cemal
dc.date.accessioned2021-06-23T18:54:55Z
dc.date.available2021-06-23T18:54:55Z
dc.date.issued2000
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of the present study was to investigate the role of the L-type voltage dependent Ca2+ channel blocker, nimodipine, in kainate induced toxicity in retinal ganglion cells of mice. Kainate in 10mg/kg was administered intraperitoneally following the vehicle or nimodipine. Nimodipine, 45 minutes prior to kainate in 10, 15, 25, 50, 100 and 250 mg/kg doses was administered intraperitoneally. Surprisingly, nimodipine potentiated the ganglional cell death induced by kainate, with respect to the control and kainate+vehicle treated group. In accordance with our results, blockage of L-type calcium channels by nimodipine may worsen the prognosis and survival of retinal neurons in kainate receptor stimulated toxicity. Blocking of calcium channels may lead to the rebound activation of sodium channels or stimulate the release of intracellular calcium by activating ryanodine sensitive calcium channels.en_US
dc.identifier.endpage217en_US
dc.identifier.issn1300-0144
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-0034084503en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage213en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4619
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0034084503&partnerID=40&md5=eee4aa81a90994447a96ccf0eabbe4ea
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGepdiremen, Akçahan Akçahan
dc.institutionauthorKaya, Murat
dc.institutionauthorKoçer, İbrahim
dc.institutionauthorGündoğdu, Cemal
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKainateen_US
dc.subjectMiceen_US
dc.subjectNeurotoxicityen_US
dc.subjectNimodipineen_US
dc.subjectRetinaen_US
dc.titleNimodipine aggravates systemic kainic acid toxicity in retinal ganglion cells of intact miceen_US
dc.typeArticleen_US

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