The relationship of vitamin D levels with hemogram indices and metabolic parameters in patients with type 2 diabetes mellitus

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dc.authorid0000-0001-7306-5233
dc.contributor.authorBaşaran, Elif
dc.contributor.authorAktaş, Gülali
dc.date.accessioned2024-09-25T20:00:09Z
dc.date.available2024-09-25T20:00:09Z
dc.date.issued2024
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü en_US
dc.description.abstractBackground: Vitamin D deficiency and Type 2 Diabetes (T2DM) are two important health problems that have rapidly increased prevalences in recent years. Chronic inflammation and susceptibility to infection are the characteristic features of T2DM. Vitamin D deficiency has been associated with high serum inflammatory marker levels due to its immunomodulatory effect. Moreover, studies have pointed out that vitamin D insufficiency could be associated with T2DM. Additionally, in recent years, inflammatory markers derived from hemogram have been associated with diabetes and its complications. Therefore, in our study, vitamin D levels, metabolic markers (i.e., serum uric acid, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol), and hemogram indices were analyzed in well controlled and poorly controlled T2DM patients. Furthermore, we compared those variables in vitamin D deficient and non-deficient groups. Methods: Laboratory data, including vitamin D and hemogram markers, were compared between poorly and well controlled T2DM patients who visited the outpatient internal medicine clinics of our institution. Results: A total of 240 T2DM individuals were included in the present study: 170 individuals had vitamin D deficiency and 70 individuals had normal vitamin D levels, who served as controls. The median neutrophil to lymphocyte ratio (NLR) value was 2.2 (0.74-7.4) in the vitamin D deficient group and 2.02 (0.73-5.56) in the vitamin D normal group (p = 0.025). Among the study parameters, the NLR and glycated hemoglobin (HbA1c) levels showed a significant positive correlation (r = 0.30, p < 0.001). The sensitivity and specificity of the NLR to predict vitamin D deficiency were determined as 60% and 49%, respectively (AUC: 0.59, p = 0.03, 95% CI: 0.51-0.67). The sensitivity and specificity of the NLR to predict an improved control of diabetes were 72% and 45%, respectively (AUC: 0.67, p < 0.001, 95% CI: 0.60-0.74). Conclusions: We think that NLR can be helpful in follow up of T2DM and vitamin D deficiency.en_US
dc.identifier.doi10.3934/medsci.2024004
dc.identifier.endpage57en_US
dc.identifier.issn2375-1576
dc.identifier.issue1en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.3934/medsci.2024004
dc.identifier.urihttps://hdl.handle.net/20.500.12491/14101
dc.identifier.volume11en_US
dc.identifier.wosWOS:001185886700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorAktaş, Gülali
dc.institutionauthorid0000-0001-7306-5233
dc.language.isoenen_US
dc.publisherAmer Inst Mathematical Sciences-Aimsen_US
dc.relation.ispartofAims Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.subjectInflammationen_US
dc.subjectInflammatory Markeren_US
dc.subjectVitamin Den_US
dc.subjectNeutrophil/Lymphocyte Ratioen_US
dc.titleThe relationship of vitamin D levels with hemogram indices and metabolic parameters in patients with type 2 diabetes mellitusen_US
dc.typeArticleen_US

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