Phenylalanine functionalized cryogels for selective cholesterol removal from milk

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dc.contributor.authorGokturk, Ilgim
dc.contributor.authorSaylan, Yeseren
dc.contributor.authorYilmaz, Fatma
dc.contributor.authorKartal, Fatma
dc.contributor.authorDenizli, Adil
dc.date.accessioned2024-09-25T19:57:35Z
dc.date.available2024-09-25T19:57:35Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractHigh cholesterol grades are a significant threat factor for coronary heart disease, which leads to heart attacks. General practices focus on lowering cholesterol and saturated fatty acids in the diet to decrease the incidence of cardiovascular diseases. Milk is a primary food with high nutritional value and high consumption. Molecularly imprinted cryogels are an excellent alternative according to non-selective methods such as liquid-liquid and/or solid-phase extraction to elute cholesterol selectively from milk. Because the cryogels are low cost, they can be synthesized easily, and the sample can be applied directly to the cryogel without needing any pre-treatment. In this study, we synthesized cholesterol-imprinted (Chl-MIP) cryogel membranes employing aminoacid-based hydrophobic functional comonomer N-methacryloyl-L-phenylalanine to be used as a selective adsorbent to remove cholesterol from milk samples. Chl-MIP cryogel exhibited a maximum Chl adsorption capacity of 12.01 mg/g at 25 degrees C with an interaction time of 60 min. The selectivity of the cryogel was 2.89 times greater for estradiol molecules and 4.99 times greater for progesterone molecules. Chl-MIP cryogel provides a rapid mass transfer by a short diffusion path without any diffusion restrictions. This process is simple to implement, efficient, affordable, and feasible for use on modern manufacturing lines.en_US
dc.description.sponsorshipHacettepe niversitesi [FHD-2018-15985]; Hacettepe University, Scientific Research Projects Coordination Uniten_US
dc.description.sponsorshipThis study is supported by Hacettepe University, Scientific Research Projects Coordination Unit (FHD-2018-15985).en_US
dc.identifier.doi10.1007/s11696-024-03392-8
dc.identifier.endpage4316en_US
dc.identifier.issn0366-6352
dc.identifier.issn2585-7290
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85188542561en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4307en_US
dc.identifier.urihttps://doi.org/10.1007/s11696-024-03392-8
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13480
dc.identifier.volume78en_US
dc.identifier.wosWOS:001190465500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Int Publ Agen_US
dc.relation.ispartofChemical Papersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectCryogelen_US
dc.subjectCholesterol removalen_US
dc.subjectMolecular imprintingen_US
dc.subjectMolecularly imprinted polymeren_US
dc.titlePhenylalanine functionalized cryogels for selective cholesterol removal from milken_US
dc.typeArticleen_US

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