Effects of magnesium sulphate on liver ischemia/reperfusion injury in a rat model

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dc.authorid0000-0002-9265-1008
dc.authorid0000-0003-2954-4784
dc.authorid0000-0002-2311-6431
dc.contributor.authorAkkoca, Kerem
dc.contributor.authorYoldaş, Hamit
dc.contributor.authorŞit, Mustafa
dc.contributor.authorKaragöz, İbrahim
dc.contributor.authorYıldız, İsa
dc.contributor.authorDemirhan, Abdullah
dc.contributor.authorBilgi, Murat
dc.date.accessioned2021-06-23T18:27:17Z
dc.date.available2021-06-23T18:27:17Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractAim: To investigate the protective efficacy of magnesium sulphate in a model of rat liver ischemiareperfusion (I/R) injury. Method: 32 adult female Wistar-Albino rats (250 to 350 g) were used in this experimental study. Rats were divided into 4 groups according to liver ischemia and magnesium sulfate application methods. Group 1 (C); control, group 2 (M); magnesium sulphate, group 3 (I/R); liver I/R, group 4 (I/R+M); I/R + magnesium sulphate treated. The blood samples were centrifuged for the study of aspartate aminotransferase (AST), alanine aminotransferase, prothrombin time (PT), international normalized ratio (INR) troponin I, total antioxidant status (TAS), total oxidant status (TOS) assays. The livers of the animals were removed at the end of the study and samples were taken for histopathological examination. Results: AST and INR values were significantly decreased in I/R+M group compared to I/R group. There was no significant difference in ALT values of the groups. Although not statistically significant, the TAS values were increased in I/R + M group compared to I/R group rats. In addition, the value of TOS was found to be lower in I/R + M group rats. In the histopathological examination, the mean values of apoptosis and necrosis were lower in the IR+M group compared to the I/R group. Conclusion: The main finding of the present study suggested that magnesium sulphate pretreatment moderately decreased the liver damage through its anti-inflammatory and anti-oxidant effects in a rat model of liver I/R.en_US
dc.identifier.doi10.30714/j-ebr.2019353194
dc.identifier.endpage102en_US
dc.identifier.issn2618-6454
dc.identifier.issn2618-6454
dc.identifier.issue3en_US
dc.identifier.startpage93en_US
dc.identifier.trdizinid362283en_US
dc.identifier.urihttps://doi.org/10.30714/j-ebr.2019353194
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpZeU1qZ3pNdz09
dc.identifier.urihttps://hdl.handle.net/20.500.12491/1635
dc.identifier.volume2en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorAkkoca, Kerem
dc.institutionauthorYoldaş, Hamit
dc.institutionauthorŞit, Mustafa
dc.institutionauthorKaragöz, İbrahim
dc.institutionauthorYıldız, İsa
dc.institutionauthorDemirhan, Abdullah
dc.institutionauthorBilgi, Murat
dc.language.isoenen_US
dc.relation.ispartofExperimental Biomedical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiver Ischemia
dc.subjectReperfusion Injury
dc.subjectMagnesium Sulfate
dc.subjectOxidative Stress
dc.subjectRat
dc.titleEffects of magnesium sulphate on liver ischemia/reperfusion injury in a rat modelen_US
dc.typeArticleen_US

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