Subanestezik konsantrasyonlarda solutulan desfluran ve sevofluranın sıçanlarda; karaciğer ve böbrek toksisitesi ile davranışları üzerine etkileri
Küçük Resim Yok
Tarih
2007
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Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Subanestezik konsantrasyonlarda anestezik gazlara kronik maruziyetin, ameliyathane personeli için zararlı olduğu birçok çalışmada gösterilmiştir. Bu çalışmadaki amacımız; desfluran ve sevofluranın subanestezik konsantrasyonlarda solutulmasının, sıçanların davranışları üzerine etkileri, karaciğer ve böbrek toksisiteleri ile biyokimyasal ve histopatolojik değişikliklerinin incelenmesiydi. Gereç ve Yöntem: Toplam 24 sıçan çalışmaya dahil edildi ve sevofluran (% 0.1), desfluran (% 0.04) ve kontrol (3 lt dk-1 O2) olmak üzere 3 gruba ayrıldı. Anestezi odasında, 4 ay süresince 09.00-13.00 saatleri arasında sıçanlar anestezik gazlara maruz bırakıldı. Anksiyete değerlendirmesi için Plus Maze Testi uygulandı; deney öncesi ve sonrasında kan örneklerinde üre, BUN, kreatinin ve GGT incelemeleri yapıldı. Deney bitiminde sıçanlar sakrifiye edilerek, karaciğer ve böbrekler histopatolojik olarak incelendi. Bulgular: Sevofluran grubunda GGT, üre ve BUN değerlerinde anlamlı artış gözlendi. Kapalı kollarda hareketsiz kalma süreleri, sevofluran ve desfluran grubunda anlamlı uzamış bulundu. Karaciğerde konjesyon, sevofluran ve desfluran grubunda kontrol grubuna göre anlamlı fazla bulundu, aynı zamanda sevofluran grubunda fokal nekroz diğer gruplardan anlamlı fazla gözlendi. Sevofluran grubunda, böbrekte fokal lenfositik infiltrasyon ve tubuler epitelde yassılaşma diğer gruplardan anlamlı fazla gözlendi. Sonuç: Bulgularımız incelendiğinde, sıçanlarda subanestezik konsantrasyonlarda sevofluran ve desfluran kullanımının anksiyeteyi arttırdığı ve bu konsantrasyondaki sevofluranın subklinik düzeyde böbrek ve karaciğerde hasara yol açabileceği sonucuna varıldı.
Aim: Numerous studies have suggested that chronic exposure to trace levels of anesthetic gas is harmful to operating room personel. In this study, we aimed to the effects of subanesthetic doses of sevoflurane and desflurane on anxiety and hepatic and renal toxicities according to biochemical and histopathological changes in rats. Material and Methods: Total 24 rats were included study and three groups were formed as sevoflurane (% 0.1), desflurane (% 0.04) and control (3 L min-1 O2). During four months, every day between 09.00-13.00 hours in the morning were inhaled with anesthetic agent determined concentrations. Anxiety were examined with Plus Maze Test; pre and post study urea, BUN, creatinine and GGT were examined in blood supplies. At the end of the study, rats were sacrificed for examined of kidney and liver histopathologically. Results: In the sevoflurane and desflurane groups increased the time spent within the closed pathways without motion. In the sevoflurane group; GGT, urea and BUN levels were elevated significantly. In the sevoflurane and desflurane groups hepatic congestion were examined significantly increased more than control group, focal necrosis increased in the sevoflurane group more than others. In the sevofluran group; focal lymphocytic infiltration and flatting in the tubuler epithelium were examined significantly higher than other groups. Conclusion: Our results were examined, subanesthetic doses of sevoflurane and desflurane were used increased to anxiety, caused of renal and hepatic damage at subclinic levels in rats.
Aim: Numerous studies have suggested that chronic exposure to trace levels of anesthetic gas is harmful to operating room personel. In this study, we aimed to the effects of subanesthetic doses of sevoflurane and desflurane on anxiety and hepatic and renal toxicities according to biochemical and histopathological changes in rats. Material and Methods: Total 24 rats were included study and three groups were formed as sevoflurane (% 0.1), desflurane (% 0.04) and control (3 L min-1 O2). During four months, every day between 09.00-13.00 hours in the morning were inhaled with anesthetic agent determined concentrations. Anxiety were examined with Plus Maze Test; pre and post study urea, BUN, creatinine and GGT were examined in blood supplies. At the end of the study, rats were sacrificed for examined of kidney and liver histopathologically. Results: In the sevoflurane and desflurane groups increased the time spent within the closed pathways without motion. In the sevoflurane group; GGT, urea and BUN levels were elevated significantly. In the sevoflurane and desflurane groups hepatic congestion were examined significantly increased more than control group, focal necrosis increased in the sevoflurane group more than others. In the sevofluran group; focal lymphocytic infiltration and flatting in the tubuler epithelium were examined significantly higher than other groups. Conclusion: Our results were examined, subanesthetic doses of sevoflurane and desflurane were used increased to anxiety, caused of renal and hepatic damage at subclinic levels in rats.
Açıklama
Anahtar Kelimeler
Endişe, Desfluran, Fare, Sevofluran, Toksisite, Anxiety, Desflurane, Rat, Sevoflurane, Toxicity
Kaynak
Türk Anestezi ve Reanimasyon Dergisi
Turkish Journal of Anaesthesiology and Reanimation
Turkish Journal of Anaesthesiology and Reanimation
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
35
Sayı
2
