Chaotic resonance in an astrocyte-coupled excitable neuron

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dc.authorid0000-0002-3681-6787en_US
dc.authorid0000-0001-6504-1653en_US
dc.contributor.authorÇalım, Ali
dc.contributor.authorBaysal, Veli
dc.date.accessioned2024-07-08T07:40:05Z
dc.date.available2024-07-08T07:40:05Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Mühendislik Fakültesi, Bilgisayar Mühendisliği Bölümüen_US
dc.description.abstractWe study the chaotic resonance phenomenon whereby the response of a neuron to a weak signal is amplified with the help of chaotic current stemming from background activity in the brain. This resonance behavior exhibits a bell-shaped curve in terms of detection quality due to increasing chaotic current intensity. Recent experimental studies have shown that astrocytes, which are the most abundant types of glial cells, may be responsible for the regulation of electrophysiological events in neuronal medium. Hence, we consider here a realistic neuronal system which is constituted by a bipartite network consisting of an excitable neuron and an astrocyte. Our analysis reveals that signal detection quality can be greatly enhanced with the astrocyte contribution obtained by appropriate neuronal and astrocytic cell dynamics. We find that depolarization -induced astrocytic glutamate release is able to improve chaotic resonance performance considerably in the presence of an adequately strong interaction between the astrocyte and the excitable neuron receiving a weak signal with a relatively higher frequency. We also show that a moderate production rate of gliotransmitters is required for the astrocyte to affect resonance performance of the neuron. Except for those conditions where the facilitating effect of astrocyte is observed, it can also reduce signal detection performance in the neuron. Furthermore, we demonstrated that intrinsic neuronal excitability is regulated by the astrocyte, via a comparison of resonance behaviors under effects of bias and astrocytic current separately. Taken together, our findings provide a novel insight into the functioning of astrocyte-neuron circuits, in particular the encoding weak signals via chaotic resonance, and suggest that astrocytes play a key role in intrinsic regulation and selectivity in neuronal information processing.en_US
dc.identifier.citationCalim, A., & Baysal, V. (2023). Chaotic resonance in an astrocyte-coupled excitable neuron. Chaos, Solitons & Fractals, 176, 114105.en_US
dc.identifier.doi10.1016/j.chaos.2023.114105
dc.identifier.endpage9en_US
dc.identifier.issn0960-0779
dc.identifier.issn1873-2887
dc.identifier.scopus2-s2.0-85172924704en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.chaos.2023.114105
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12243
dc.identifier.volume176en_US
dc.identifier.wosWOS:001088791000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÇalım, Ali
dc.language.isoenen_US
dc.publisherPergamon-Elseiver Science Ltden_US
dc.relation.ispartofChaos, Solitons & Fractalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAstrocyteen_US
dc.subjectBipartite Networken_US
dc.subjectSignal Detectionen_US
dc.subjectStochastic Resonanceen_US
dc.subjectHuman Brainen_US
dc.subjectGlutamateen_US
dc.titleChaotic resonance in an astrocyte-coupled excitable neuronen_US
dc.typeArticleen_US

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