Pioglitazone improves ventricular diastolic function in patients with diabetes mellitus: A tissue Doppler study

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dc.authorscopusid25121970100
dc.authorscopusid8615642100
dc.authorscopusid35274318900
dc.authorscopusid35274448800
dc.authorscopusid35338946100
dc.authorscopusid36105714600
dc.authorscopusid7007162316
dc.contributor.authorOrdu, Serkan
dc.contributor.authorOzhan, Hakan
dc.contributor.authorAlemdar, Recai
dc.contributor.authorAydin, Mesut
dc.contributor.authorBasar, Cengiz
dc.contributor.authorCaglar, Onur
dc.contributor.authorYazici, Mehmet
dc.date.accessioned2024-09-25T19:42:53Z
dc.date.available2024-09-25T19:42:53Z
dc.date.issued2010
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective - Pioglitazone treatment in type 2 diabetes mellitus produced significant improvements in glycaemic control, plasma lipids, blood pressure and inflammation. The aim of this study was to investigate the effect of pioglitazone on systolic and diastolic function in diabetic patients. Methods and results - Forty-nine diabetic patients were included in the study.The patients had never received thiazolidinedione therapy before. Clinical and echocardiographic variables were measured. 30 mg pioglitazone were administered. The patients were followed up for six months and all the measurements were re-evaluated for comparison. Body mass index (BMI) significantly increased after treatment. Fasting glucose, HbA1c and systolic blood pressure decreased. Insulin resistance improved and the HOMA-IR index decreased after pioglitazone treatment. Mean aortic diameter, left atrial systolic and diastolic volumes significantly decreased after therapy. Among diastolic function variables mitral E wave, E/A, ejection time and pulmonary vein peak reverse flow velocity (PVA) significantly increased whereas isovolumetric relaxation time (IVRT), isovolumetric contraction time (IVCT), deceleration time, E/E' and pulmonary vein late systolic flow (PVS2) decreased after pioglitazone therapy. Among tissue Doppler variables early (E) ventricular inflow velocities measured from the tricuspid lateral annulus, the mitral septal and lateral annulus, the anterior, inferior and posterior free wall significantly increased. Late (A) ventricular inflow velocities measured from the anterior, inferior free wall and the mitral septal annulus also increased. Conclusion - Pioglitazone treatment in type 2 diabetes mellitus produced significant improvements in measures of glycaemic control and diastolic ventricular function.en_US
dc.identifier.doi10.2143/AC.65.4.2053898
dc.identifier.endpage406en_US
dc.identifier.issn0001-5385
dc.identifier.issue4en_US
dc.identifier.pmid20821932en_US
dc.identifier.scopus2-s2.0-78049245845en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage401en_US
dc.identifier.urihttps://doi.org/10.2143/AC.65.4.2053898
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12338
dc.identifier.volume65en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cardiologicaen_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectDiastolic functionen_US
dc.subjectPioglitazoneen_US
dc.subjectType 2 diabetes mellitusen_US
dc.titlePioglitazone improves ventricular diastolic function in patients with diabetes mellitus: A tissue Doppler studyen_US
dc.typeArticleen_US

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