A winning two pair: Role of the redox pairs AsA/DHA and GSH/GSSG in signal transduction

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dc.authorid0000-0003-0548-174Xen_US
dc.authorid0000-0003-0060-259X
dc.contributor.authorŞahin, Günce
dc.contributor.authorDe Tullio, Mario C.
dc.date.accessioned2021-06-23T19:27:17Z
dc.date.available2021-06-23T19:27:17Z
dc.date.issued2010
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractFor a few decades after its identification, the AsA/GSH (Halliwell-Asada) cycle has been almost exclusively considered as a scavenging system, more or less efficiently removing reactive oxygen species (ROS). The whole issue was simplistically viewed as a fight between "bad" ROS and "good" antioxidants until recently, when ROS (and reactive nitrogen species, RNS) were identified as important signalling molecules, inducing an array of defensive responses in both animal and plant systems. In this framework, antioxidants take a completely different role, becoming part of complex signalling modules. AsA and GSH are connected in many ways, forming a functional entity. Still they have their own specificity and control different aspects of plant metabolism and growth. It is increasingly clear that AsA and GSH, together with their oxidized forms, have a pivotal, multi-level regulatory role in protein function and gene expression. Remarkable progress has been recently achieved in the identification of transcription factors and other proteins, whose activity is regulated by changes in the relative amount of redox components. Additionally, participation of AsA as a co-substrate of reactions catalysed by dioxygenases (a large class of enzymes involved in hormone synthesis and post-translational protein modification), also has a relevant regulatory role.en_US
dc.identifier.doi10.1007/978-90-481-9404-9_9
dc.identifier.endpage263en_US
dc.identifier.isbn978-90-481-9404-9; 978-90-481-9403-2
dc.identifier.scopus2-s2.0-84919617333en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage251en_US
dc.identifier.urihttps://doi.org/10.1007/978-90-481-9404-9_9
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6778
dc.identifier.wosWOS:000281576300009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorŞahin, Günce
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAscorbate-Glutathione Pathway And Stress Tolerance In Plantsen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAscorbic Aciden_US
dc.subjectGlutathioneen_US
dc.subjectRedox Regulationen_US
dc.subjectEvolution of Metabolismen_US
dc.titleA winning two pair: Role of the redox pairs AsA/DHA and GSH/GSSG in signal transductionen_US
dc.typeBook Chapteren_US

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