Thrombotic, fibrinolytic and proliferative activities of pulmonary vascular bed in secondary pulmonary hypertension

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dc.contributor.authorErgün, Kumral
dc.contributor.authorBalbay, Yücel
dc.contributor.authorCihan, Gökhan
dc.contributor.authorAras, Dursun
dc.contributor.authorÇaǧli, Kerim
dc.contributor.authorAyaz, Selin
dc.contributor.authorBilgiç, Filiz
dc.contributor.authorBalbay, Öner A.
dc.contributor.authorŞaşmaz, Hatice
dc.contributor.authorKorkmaz, Şule
dc.date.accessioned2021-06-23T18:54:27Z
dc.date.available2021-06-23T18:54:27Z
dc.date.issued2005
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To determine whether pulmonary vascular bed contributes to the development of in situ thrombosis and vascular remodelling in secondary pulmonary hypertension (SPH) via changes in its local secretory activities. Methods: Seventy-one patients with the diagnosis of secondary pulmonary hypertension (38 females, mean age 40.36± 1.05 years) were included in the study. Selective right and left heart catheterization was performed to each patient for diagnostic purposes. Blood samples obtained from left ventricle (LV) and pulmonary artery (PA) of each patient were analyzed for levels of plasminogen activator inhibitor-1 (PAI-1), platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF), D-dimer, von Willebrand factor (vWF), protein-C, antithrombin-III, fibrinogen, and plasminogen. Results were compared between LV and PA. Correlation analysis between each parameter and mean pulmonary artery pressure (MPAP) was performed. Results: Although mean level of VEGF in LV and PA were found to be in normal range, it was significantly higher in LV than in PA (p<0.001). Mean PDGF and D-dimer levels, which remained in normal range were also higher in LV (p<0.001 and p<0.001, respectively) than in PA;.vWF showed similar degree of elevation in both LV and PA. Only one parameter, PAI-1, was found to be significantly higher in PA than in LV (p=0.012). Antithrombin-III, protein C, plasminogen, and fibrinogen levels showed no significant differences between two chambers. They also remained in normal range, except for fibrinogen, which was slightly elevated in both LV and PA. Correlation analysis revealed strong positive correlation between D-dimer level in both LV and PA and MPAP (r=0.775, p<0.001 and r=0.649, p<0.001, respectively). Conclusion: In SPH, pulmonary vascular bed shows increased thrombotic, hypofibrinolytic, and proliferative activities, which are partially related to the severity of illness.en_US
dc.identifier.endpage100en_US
dc.identifier.issn1302-8723
dc.identifier.issue2en_US
dc.identifier.pmid15939682en_US
dc.identifier.scopus2-s2.0-20844461355en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4439
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-20844461355&partnerID=40&md5=6e2798c02d4bf66c84d659fe77018c59
dc.identifier.volume5en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErgün, Kumral
dc.institutionauthorBalbay, Yücel
dc.institutionauthorCihan, Gökhan
dc.institutionauthorAras, Dursun
dc.institutionauthorÇaǧli, Kerim
dc.institutionauthorAyaz, Selin
dc.institutionauthorBilgiç, Filiz
dc.institutionauthorBalbay, Öner A.
dc.institutionauthorŞaşmaz, Hatice
dc.institutionauthorKorkmaz, Şule
dc.language.isotren_US
dc.relation.ispartofAnadolu Kardiyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic intravascular coagulationen_US
dc.subjectGrowth factorsen_US
dc.subjectSecondary pulmonary hypertensionen_US
dc.titleThrombotic, fibrinolytic and proliferative activities of pulmonary vascular bed in secondary pulmonary hypertensionen_US
dc.title.alternativeSekonder pulmoner hipertansiyonda pulmoner vasküler yata?ın trombotik, fibrinolitik ve proliferatif aktivitelerien_US
dc.typeArticleen_US

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