Histopathologic examination of the effects of cyclosporin A alone and the combined therapy with prednisolone on lung: An experimental study
Yükleniyor...
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cambridge University Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Cyclosporin-A(CsA) is a very potent immunosuppressive agent which is widely used in
transplantations and autoimmune diseases. Recent studies suggest an encouraging clinical effect
for low-dose, long-term cyclosporin A treatment in different lung diseases[1,2,3,4,5]. Whether
administration of CsA might be useful for lowering the dosage of steroids during the treatment of
interstitial pneumonia, asthma and lung injuries[6,7,8] is presently a matter of controversy.
Several clinical studies reported that CsA might cause pulmonary complications in transplant
recipients [9,10].
The aims of this experimental study were: (i) to examine the effects of CsA on lung at
morphologic level and to verify the tolerability of long-term, low-dose treatment with this drug;
(ii) to analyze if Cremophor-EL(the vehicle in the intravenous form of CyA) is responsible from
the changes; (iii) to investigate if combined therapy with Prednisolone has better morphologic
results on lung tissue.
Forty-eight female Sprague-Dawley rats were divided into four groups: Group I was control.
The other three group had daily intraperitoneal injection of 4mg/kg/day CyA for 2,5 months.
Group II had oral, Group III had intravenous form of this drug while Group IV had intravenous
form of CsA with 1 mg/kg/day prednisolone. Biopsy specimens from lung were embedded in
paraffin and the sections were stained with Hematoxylene & Eosin for microscopic examination.
Açıklama
Anahtar Kelimeler
Histopathologic, Combined Therapy
Kaynak
Microscopy and Microanalysis
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
9
Sayı
SUPPL. 2
