Psoriasisde prolaktinin rolü
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Dosyalar
Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Prolaktinin (PRL) çok iyi bilinen çeşitli biyolojik etkilerinin yanında, hücresel ve humoral immünitenin önemli bir in vivo modülatörü olduğu, deri epitel hücre proliferasyonunu ve deri immün sistemini etkilediği bildirilmiştir. Bu çalışmada, etyolojisi hala anlaşılamamış, epidermal hiperplazi ve diskeratinizasyon ile karakterize, yaygın inflamatuar bir deri hastalığı olan psoriasis ile serum prolaktin düzeyleri arasında bir ilişki olup olmadığı araştırıldı. Klinik veya histopatolojik olarak psoriasis tanısı alan 34 olgu çalışma grubuna alındı. Kontrol grubu 21 sağlıklı kişiden oluşturuldu. Serum prolaktin düzeyleri, "chemiluminescent" enzim immünometrik yöntemle, DPC ticari kitleri kullanılarak "Immulite One" hormon analizöründe ölçüldü. Psoriasisli hastalarda saptanan serum prolaktin düzeyleri (ortalama ± SD: 8,9±5,4 ng/ml), kontrol grubu düzeyleri (ortalama ± SD: 9,13+5,18 ng/ml) ile karşılaştırıldığında anlamlı bir fark saptanmadı (p= 0,548). Son yıllarda, prolaktinin immün reaksiyonlarda önemli bir yeri olduğu ve keratinositlerde proliferatif bir etki gösterdiği anlaşılmıştır. Ancak bizim çalışmamızda, psoriasisli hastalarda serum prolaktin düzeylerinin yükselmediği saptandı. PRL'in epitel hücrelerin proliferasyonunda ve immünregülasyonda oynadığı rolü destekleyen güçlü veriler olduğu dikkate alındığında, bu konuda daha fazla çalışma yapılması gerektiği düşünüldü.
Background: Despite its well known a variety of biological activities, it has been suggested that prolactin acts as an important in vivo modulator of cellular and humoral immunity and has some effects about skin epithelial cell proliferation and skin immune system. Objective: It was studied whether the relationship between psoriasis, which is a common inflammatory skin disease of still obscure etiology characterized by epidermal hyperplasia and dyskeratinization, and serum levels of prolactin. Materials and Methods: Serum levels of prolactin were estimated in 34 patients with psoriasis and the results were compared with those in 21 normal control subjects. Serum levels of prolactin were measured with chemi luminescent enzyme immunometric assay by using DPC commercial kits on Immulite One hormone analyser. Results: When serum prolactin levels in patients with psoriasis (mean ± SD: 8,9±5,4 ng/ml) were compared with those in normal control subjects (mean ± SD: 9,13±5,18 ng/ml), it was no significant difference between two groups (p= 0.548). Conclusion: In recent years, it has become apparent that prolactin plays an important part in the immune reactions and exerts a proliferative effect on human keratinocytes. But in our study, serum prolactin levels were not found significantly higher in patients with psoriasis. When it was took into consideration that there were powerful data supported the role of prolactin in epithelial proliferation and immunoregulation, it was thought that it should be performed further studies on this topic.
Background: Despite its well known a variety of biological activities, it has been suggested that prolactin acts as an important in vivo modulator of cellular and humoral immunity and has some effects about skin epithelial cell proliferation and skin immune system. Objective: It was studied whether the relationship between psoriasis, which is a common inflammatory skin disease of still obscure etiology characterized by epidermal hyperplasia and dyskeratinization, and serum levels of prolactin. Materials and Methods: Serum levels of prolactin were estimated in 34 patients with psoriasis and the results were compared with those in 21 normal control subjects. Serum levels of prolactin were measured with chemi luminescent enzyme immunometric assay by using DPC commercial kits on Immulite One hormone analyser. Results: When serum prolactin levels in patients with psoriasis (mean ± SD: 8,9±5,4 ng/ml) were compared with those in normal control subjects (mean ± SD: 9,13±5,18 ng/ml), it was no significant difference between two groups (p= 0.548). Conclusion: In recent years, it has become apparent that prolactin plays an important part in the immune reactions and exerts a proliferative effect on human keratinocytes. But in our study, serum prolactin levels were not found significantly higher in patients with psoriasis. When it was took into consideration that there were powerful data supported the role of prolactin in epithelial proliferation and immunoregulation, it was thought that it should be performed further studies on this topic.
Açıklama
Anahtar Kelimeler
Prolaktin, Psoriasis, Keratinosit Proliferasyonu, Prolactin, Psoriasis, Keratinocyte Proliferation
Kaynak
Türkderm-Deri Hastalıkları ve Frengi Arşivi
Turkderm-Turkish Archives of Dermatology and Venereology
Turkderm-Turkish Archives of Dermatology and Venereology
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
36
Sayı
4
