Kronik hepatit B enfeksiyonlu hastalarda Anti-HDV ve HDAg prevalansı
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Dosyalar
Tarih
2013
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada, Ağrı ilinde kronik hepatit B enfeksiyonu tanısıyla takip edilen hastaların anti-HDV ve HDAg test sonuçlarının korelasyonunun irdelenmesi ve HDV epidemiyolojisine ait veri toplaması amaçlandı. Gereç ve yöntem: Ağrı Devlet Hastanesi Ocak 2009-Mayıs 2012 tarihleri arasında gastroenteroloji ve enfeksiyon hastalıkları tarafından kronik hepatit B tanısıyla takip edilen hastaların anti-HDV, HDAg sonuçları ve demografik verileri retrospektif olarak incelendi. HBs Ag, Anti-HBc IgM tetkikleri makroeliza, anti-HDV ve HDAg tetkikleri ise mikroeliza yöntemiyle çalışıldı. Bulgular: Çalışmaya 315’i (%40,0) kadın, 472’si (%60,0) erkek olmak üzere toplam 787 hasta dahil edildi. Hastaların tamamında HBs Ag pozitif ve anti HBc IgM negatif olarak saptandı. Bu hastalardan 55’inde (%7,0) sadece Anti-HDV, 19(%2,4)’unda sadece HDAg pozitif olarak saptandı. İki (%0,3) olguda ise Anti-HDV ve HDAg birlikte saptandı. Toplam 76(%9,7) hastada HDV lehine pozitif bulgu saptandı. HDV pozitif hastaların yaş ortalaması 42,1±15,2 (11-77 yaş) olarak tespit edildi. Bunların 36’sı %47,4) kadın, 40’ı (%52,6) erkekti.Sonuç: Kronik viral hepatit hastalarında HDV enfeksiyonu hala önemini korumaktadır. Çalışmamızda HDV en- feksiyon oranı %9,7 olarak tespit edilmiştir. Bu oran, aynı bölgeden daha önce bildirilen çalışmalardan daha düşük olmasına rağmen ülke ortalamasının üzerindedir.
Objective: In this study, it is aimed to evaluate the corre lation of the test results of anti-HDV and HDAg in patients with chronic HBV infection and to collect data concerning HDV epidemiology. Materials and methods: Anti-HDV and HDAg test results and demographic data of the patients with chronic HBV infection by gastroenterology and infectious diseases in Agri State Hospital between January 2009-May 2012 were analyzed retrospectively. HBsAg and Anti-HBc IgM tests were performed with macroelisa, anti-HDV and HDAg were tested with microelisa. Results: A total of 787 patients constituting 315(40.0%) females and 472(60.0%) males were included in the study. All the patients were HBsAg positive and Anti-HBc IgM negative. Of these patients, 55(7.0%) cases were only anti-HDV positive; 19(2.4%) were only HDAg posi tive and two cases were both anti-HDV and HDAg posi tive. A total of 76(9.7%) patients had positive findings of HDV infection. The mean age of HDV-positive patients was 42.1±15.2 (11-77 years); of these 36(47.4) were fe male and 40(52.6) were male. Conclusion: In patients with chronic viral hepatitis, HDV infection still remains significant. In our study HDV infec tion rate was detected as 9.7%. Although this rate is lower than the earlier reports of the same region, it is above the national average.
Objective: In this study, it is aimed to evaluate the corre lation of the test results of anti-HDV and HDAg in patients with chronic HBV infection and to collect data concerning HDV epidemiology. Materials and methods: Anti-HDV and HDAg test results and demographic data of the patients with chronic HBV infection by gastroenterology and infectious diseases in Agri State Hospital between January 2009-May 2012 were analyzed retrospectively. HBsAg and Anti-HBc IgM tests were performed with macroelisa, anti-HDV and HDAg were tested with microelisa. Results: A total of 787 patients constituting 315(40.0%) females and 472(60.0%) males were included in the study. All the patients were HBsAg positive and Anti-HBc IgM negative. Of these patients, 55(7.0%) cases were only anti-HDV positive; 19(2.4%) were only HDAg posi tive and two cases were both anti-HDV and HDAg posi tive. A total of 76(9.7%) patients had positive findings of HDV infection. The mean age of HDV-positive patients was 42.1±15.2 (11-77 years); of these 36(47.4) were fe male and 40(52.6) were male. Conclusion: In patients with chronic viral hepatitis, HDV infection still remains significant. In our study HDV infec tion rate was detected as 9.7%. Although this rate is lower than the earlier reports of the same region, it is above the national average.
Açıklama
Anahtar Kelimeler
HDV, HDAg, Delta Antijeni, Anti-HDV, Kronik Hepatit B, Ağrı, Delta Antigen, Chronic Hepatitis B, Pain
Kaynak
Dicle Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
40
Sayı
1
