Evaluation of cytotoxic effect of garlic on human gingival fibroblasts: A Preliminary study
Yükleniyor...
Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Çalışmamızda insan diş eti fibroblastları üzerine sarımsak özütünün sitotoksisitesi araştırıldı. %12.5, 6.25, 3.12, 1.5 ve 0.6’lık derişimlerde olmak üzere 5 farklı sarımsak çözeltisi hazırlandı. Klorheksidin glukonat ve sarımsağın insan dişeti fibroblastları üzerine olan sitotoksik etkileri 24. saatte agar difüzyon metodu ile değerlendirildi. % 6.25, 3.12 ve 1.5’lik derişimlerdeki sarımsak çözeltileri her hangi bir sitotoksik etki göstermemiştir. %12.5’luk derişimdeki sarımsak çözeltisi sitotoksik etki göstermiştir, bu etki klorheksidin glukonatın gösterdiğinden daha az bulunmuştur. Bu ön çalışmadan elde edilen verilere göre sarımsak çözeltisi ile hazırlanacak uygun solüsyonlar ağız sağlığının elde edilmesi yönünde gelecekte kullanılabilir.
In this study we aimed to evaluate the cytotoxic effect of garlic extract on human gingival fibroblasts. Garlic extracts were prepared at 5 different concentrations as 12.5%, 6.25%, 3.12%, 1.5%, and 0.6%. Cytotoxic effects of garlic and clorhexidine gluconat (CH) on human gingival fibroblasts were evaluated by agar diffusion method at 24 h. Garlic extracts concentrations at 6.25, 3.12, and 1.5% were not found cytotoxic on human gingival fibroblasts, whereas concentration at 12.5% was found cytotoxic, this effect was found less cytotoxic than CH. According to results of this study we could suggest that Garlic would have a promising role in the future for oral health, if appropriate solutions can be prepared.
In this study we aimed to evaluate the cytotoxic effect of garlic extract on human gingival fibroblasts. Garlic extracts were prepared at 5 different concentrations as 12.5%, 6.25%, 3.12%, 1.5%, and 0.6%. Cytotoxic effects of garlic and clorhexidine gluconat (CH) on human gingival fibroblasts were evaluated by agar diffusion method at 24 h. Garlic extracts concentrations at 6.25, 3.12, and 1.5% were not found cytotoxic on human gingival fibroblasts, whereas concentration at 12.5% was found cytotoxic, this effect was found less cytotoxic than CH. According to results of this study we could suggest that Garlic would have a promising role in the future for oral health, if appropriate solutions can be prepared.
Açıklama
Anahtar Kelimeler
Garlic, Chlorhexidin Gluconat, Human Gingival Fibroblast, Cytotoxicity, Sarımsak, Klorheksidin Glukonat, İnsan Dişeti Fibroblastı, Sitotoksisite
Kaynak
Gülhane Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
55
Sayı
4
