Diagnostic value of mid-regional pro-atrial natriuretic peptide (MR-proANP) level in patients with acute pulmonary embolism

dc.authorid0000-0001-6807-643Xen_US
dc.authorid0000-0002-3839-7651en_US
dc.authorid0000-0002-9617-8772en_US
dc.authorid0000-0003-4791-8946en_US
dc.authorid0000-0002-9991-3939en_US
dc.contributor.authorAltuğ, Ertuğrul
dc.contributor.authorKara, Hasan
dc.contributor.authorBayır, Ayşegül
dc.contributor.authorAk, Ahmet
dc.contributor.authorKayış, Seyit Ali
dc.contributor.authorÜnlü, Ali
dc.date.accessioned2024-01-12T12:14:03Z
dc.date.available2024-01-12T12:14:03Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: Right ventricular failure can develop in patients with pulmonary embolism (PE) and is associated with increased mortality. Mid-regional pro-atrial natriuretic peptide (MR-proANP), a natriuretic peptide, is secreted due to the increased atrial wall tension caused by right heart failure. In this study, we aimed to investigate the diagnostic value of MR-proANP in patients who presented to the emergency department with a pre-diagnosis of pulmonary embolism.Material and Methods: Among patients with a preliminary diagnosis of PE, 100 patients who were confirmed to have PE by computed tomography pulmonary angiography (CTPA) were determined as the case group. As a control group, 50 patients were randomly identified, in whom the diagnosis of PE was excluded. Echocardiography was performed in all patients in the case group immediately after the diagnosis was confirmed, and the presence of right ventricular dysfunction was investigated. This study was designed as a prospective observational study.Results: The median value of MR-proANP (645.8 (66.37-3313.08) pmol/L) in the case group was found to be significantly higher than median value of MR-proANP (442.9 (226.73-774.78) pmol/L) in the control group (p:0.003). MR-proANP was found to be significantly higher in the differential diagnosis of PE.Discussion: In addition to clinical signs and symptoms, MR-proANP levels seem to be a useful variable that may improve diagnostic accuracy in patients with suspected pulmonary embolism in the emergency department.en_US
dc.identifier.citationAltuğ, E., Kara, H., Bayır, A., Ak, A., Kayış, S. A., Ünlü, A., ... & Tezcan, H. Diagnostic value of mid-regional pro-atrial natriuretic peptide (MR-proANP) level in patients with acute pulmonary embolism.en_US
dc.identifier.doi10.4328/ACAM.21399
dc.identifier.endpage24en_US
dc.identifier.issn2667-663X
dc.identifier.issue1en_US
dc.identifier.startpage21en_US
dc.identifier.urihttp://dx.doi.org/10.4328/ACAM.21399
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11929
dc.identifier.volume14en_US
dc.identifier.wosWOS:000964339100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorKayış, Seyit Ali
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical And Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTextile Dyeing Sludgeen_US
dc.subjectMR-proANP Acute Pulmonary Embolismen_US
dc.subjectRight Ventricular Failureen_US
dc.subjectBiomarkeren_US
dc.subjectPrognostic Valueen_US
dc.subjectEchocardiographyen_US
dc.titleDiagnostic value of mid-regional pro-atrial natriuretic peptide (MR-proANP) level in patients with acute pulmonary embolismen_US
dc.typeArticleen_US

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